2-苄氧羰基氨基-1-乙醇合成路线 （共 31 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
UCL BUSINESS PLC
Patent: WO2009/27679 A1, 2009 ;
Location in patent: Page/Page column 49 ;
参考文献
Manoharan, Muthiah; Prakash, Thazha P.; Rajeev, Kallanthottathil G.
Patent: US2004/33973 A1, 2004 ;
Location in patent: Page/Page column 56 ;
反应条件
triphenylphosphine in tetrahydrofuran T=20°C;
参考文献
3-Dimensional Pharmaceuticals, Inc.
Patent: US6417161 B1, 2002 ;
反应条件
1: Et3N / CH2Cl2 / 1.) 0 deg C, 30 min, 2.) RT, 30 min 2: dimethylformamide / 3 h / 60 °C 3: 71 percent / NaBH4, NiCl2*6H2O / methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Constantinou-Kokotou, Violetta; Kokotos, George
Organic Preparations and Procedures International, 1994 , vol. 26, # 5 p. 599 - 602
反应条件
sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine in dichloromethane
T=-20°C; 1 h;
参考文献
Theravance, Inc.
Patent: US2009/62335 A1, 2009 ;
Location in patent: Page/Page column 12 ;
US 20090062335 A1
反应条件
tert.-butylhydroperoxide; Caldariomyces fumago chloroperoxidase in aq. acetate buffer
T=20 - 23°C; pH=5; 30 h; Enzymatic reaction;
参考文献
Pesic, Milja; Lopez, Carmen; Alvaro, Gregorio; Lopez-Santin, Josep
Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 84, p. 144 - 151
反应条件
triethylamine in dichloromethane; dimethyl sulfoxide
参考文献
Abbott Laboratories
Patent: US5914332 A1, 1999 ;
US 5914332 A
反应条件
1H-imidazole; iodine; triphenylphosphine in dichloromethane
T=0°C; 0.25 h;
参考文献
Van Staveren, Dave R.; Mundwiler, Stefan; Hoffmanns, Ulrich; Pak, Jae Kyoung; Spingler, Bernhard; Metzler-Nolte, Nils; Alberto, Roger
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 18 p. 2593 - 2603
反应条件
1: 95 percent / Jones' reagent / acetone / 3 h / 0 °C
2: 52 percent / DCC / CH2Cl2 / 10 h / Ambient temperature
View Scheme
参考文献
Kashima, Choji; Harada, Kazuo; Fujioka, Yoko; Maruyama, Tatsuya; Omote, Yoshimori
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 535 - 540
反应条件
pyridine; chloroform
Beim Behandeln anschliessend Hydrieren des Reaktionsprodukts in mit wss. Perchlorsaeure versetztem Aethanol an Palladium/Kohle und anschliessend an Platin;
参考文献
Jones; Lipkin
Journal of the American Chemical Society, 1956 , vol. 78, p. 2408,2409
