1: ethyl 3-oxo-3-phenylpropionate; N,N-dimethyl-formamide dimethyl acetal T=130°C; 0.166667 h; Microwave irradiation; 2: 2-methyl-2-thiopseudourea sulfate With sodium ethanolate in ethanol 2.5 h; Heating / reflux;

1: With sodium hydrogencarbonate in N,N-dimethyl-formamide T=75°C; Biginelli type reaction; 2: With 2-hydroxy-1,3-isoindolinedione; oxygen; [Co(O2CCH3)2]*4H2O in dichloromethane T=80°C; P=760.051 Torr; 0.5 h;

sodium acetate in N,N-dimethyl-formamide T=80 - 90°C; 12 h;

sodium ethanolate in ethanol Heatingreflux overnight;

1: S-methylisothiourea sulfate; ethyl 3-oxo-3-phenylpropionate; isobutyraldehyde With sodium hydrogencarbonate in N,N-dimethyl-formamide T=75°C; Biginelli three-component-coupling; 2: tert.-butylhydroperoxide With potassium carbonate; copper dichloride in dichloromethane; water T=38 - 40°C;

1: 91 percent / benzene / 0.5 h / Heating 2: 77 percent / sodium ethoxide / ethanol / Heating; reflux overnight View Scheme

1: 81 percent / 2 N NaOH / Ambient temperature 2: 69 percent / 18 h / Heating View Scheme