3,3-双(氯甲基)氧杂环丁烷合成路线 （共 32 条）
反应条件
1: 76 percent / sodium azide / dimethylformamide / 2 h / 90 - 100 °C
2: 96.5 percent / 47percent hydrobromic acid / CH2Cl2 / 2 h / Heating
3: 77 percent / sodium azide / dimethylsulfoxide / 48 h / 85 - 90 °C
View Scheme
参考文献
Wilson, Edgar R.; Frankel, Milton B.
Journal of Organic Chemistry, 1985 , vol. 50, # 17 p. 3211 - 3212
反应条件
sodium hydroxide
T=120°C; 0.666667 h;
参考文献
Zarudii, F. S.; Lazareva, D. N.; Kurmaeva, E. S.; Chalova, O. B.; Kiladze, T. K.; et al.
Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 2 p. 108 - 111
Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 2 p. 161 - 165
反应条件
ethanol; sodium thiosulfate
参考文献
Campbell
Journal of Organic Chemistry, 1957 , vol. 22, p. 1029,1033
反应条件
chlorine in tetrachloromethane
参考文献
V'yunov,K.A. et al.
Journal of Organic Chemistry USSR (English Translation), 1976 , vol. 12, p. 2263 - 2267
Zhurnal Organicheskoi Khimii, 1976 , vol. 12, # 11 p. 2331 - 2335
反应条件
sulfuric acid in toluene
T=110°C; 4.5 h;
参考文献
Kireev, I. R.; Kantor, E. A.; Valitov, R. B.; Rakhmankulov, D. L.
Journal of Organic Chemistry USSR (English Translation), 1981 , p. 1366 - 1368
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 7 p. 1536 - 1539
反应条件
1: conc. H2SO4 / dioxane / 5 h / Heating
2: 22 percent / NaI / acetone / 175 h / 62 °C
View Scheme
参考文献
Kurmaeva, E. S.; Chalova, O. B.; Chistoedova, G. P.; Lapuka, L. F.; Kiladze, T. K.; et al.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 1 p. 119 - 123
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 1 p. 131 - 135
反应条件
sulfuric acid in toluene
T=100°C; 4.5 h;
参考文献
Kireev, I. R.; Kantor, E. A.; Valitov, R. B.; Rakhmankulov, D. L.
Journal of Organic Chemistry USSR (English Translation), 1981 , p. 1366 - 1368
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 7 p. 1536 - 1539
反应条件
sulfuric acid in 1,4-dioxane
5 h; Heating;
参考文献
Kurmaeva, E. S.; Chalova, O. B.; Chistoedova, G. P.; Lapuka, L. F.; Kiladze, T. K.; et al.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 1 p. 119 - 123
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 1 p. 131 - 135
反应条件
1: 75 percent / NaI / acetone / 52 h / Heating
2: 86 percent / conc. H2SO4 / dioxane / 5 h / Heating
View Scheme
参考文献
Kurmaeva, E. S.; Chalova, O. B.; Chistoedova, G. P.; Lapuka, L. F.; Kiladze, T. K.; et al.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 1 p. 119 - 123
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 1 p. 131 - 135
参考文献
V'yunov,K.A. et al.
Journal of Organic Chemistry USSR (English Translation), 1976 , vol. 12, p. 2263 - 2267
Zhurnal Organicheskoi Khimii, 1976 , vol. 12, # 11 p. 2331 - 2335
