异丁胺合成路线 - 魔法化学

参考文献

Iwahara; Yanagimachi; Kamiya; Nakadate; Suzuki
Chemical and pharmaceutical bulletin, 1971 , vol. 19, # 9 p. 1914 - 1918

75-21-8环氧乙烷+

78-81-9异丁胺

30769-76-7N-异丁基二乙醇胺

参考文献

Mistry; Abraham; Hanin
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 376 - 380

78-81-9异丁胺+

30720-25-34-氯-1-乙基-1H-吡唑[3,4-b]吡啶-5-羧酸乙酯

34966-24-0

参考文献

Hamblin, J. Nicole; Angell, Tony D.R.; Ballantine, Stuart P.; Cook, Caroline M.; Cooper, Anthony W.J.; Dawson, John; Delves, Christopher J.; Jones, Paul S.; Lindvall, Mika; Lucas, Fiona S.; Mitchell, Charlotte J.; Neu, Margarete Y.; Ranshaw, Lisa E.; Solanke, Yemisi E.; Somers, Don O.; Wiseman, Joanne O.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 4237 - 4241

78-81-9异丁胺+

105-36-2溴乙酸乙酯

3182-85-2

参考文献

Greco,C.V. et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 861 - 865

78-81-9异丁胺+

98760-08-8(1S)-1-(2R)-环氧乙基-2-苯乙基氨基甲酸叔丁酯

160232-08-6[(1S,2R)-2-羟基-3-[(2-甲基丙基)氨基]-1-(苯基甲基)丙基]-1,1,-二甲基乙酯

参考文献

TIBOTEC BVBA
Patent: US2010/305073 A1, 2010 ;
Location in patent: Page/Page column 21-22 ;

78-81-9异丁胺

160232-08-6[(1S,2R)-2-羟基-3-[(2-甲基丙基)氨基]-1-(苯基甲基)丙基]-1,1,-二甲基乙酯

参考文献

G. D. Searle and Co.
Patent: US6388132 B1, 2002 ;
Location in patent: Page column 44 ;

78-81-9异丁胺+

165727-45-7(1S,2S)-(1-苄基-3-氯-2-羟基丙基)氨基甲酸叔丁酯

160232-08-6[(1S,2R)-2-羟基-3-[(2-甲基丙基)氨基]-1-(苯基甲基)丙基]-1,1,-二甲基乙酯

参考文献

MYLAN LABORATORIES LTD; VELLANKI, Siva Rama Prasad; SAHU, Arabinda; PHADHURI, Naveen Kumar; KILARU, Ravindrababu
Patent: WO2013/114382 A1, 2013 ;
Location in patent: Page/Page column 7 ;

1229623-13-5+

78-81-9异丁胺

160232-08-6[(1S,2R)-2-羟基-3-[(2-甲基丙基)氨基]-1-(苯基甲基)丙基]-1,1,-二甲基乙酯

参考文献

MATRIX LABORATORIES LIMITED; VELLANKI, Siva Rama Prasad; SAHU, Arabinda; KATUKURI, Aravind Kumar; VANAMA, Vikram; KOTHARI, Satishbabu; PONNEKANTI, Venkata Suryanarayana; DATTA, Debashish
Patent: WO2011/48604 A2, 2011 ;
Location in patent: Page/Page column 18 ;

78-81-9异丁胺+

220871-52-3

160232-08-6[(1S,2R)-2-羟基-3-[(2-甲基丙基)氨基]-1-(苯基甲基)丙基]-1,1,-二甲基乙酯

参考文献

HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; VAMSI KRISHNA, Bandi; MANOHAR SHARMA, Vedula; RATHNAKAR REDDY, Kura; MADHANMOHAN REDDY, Musku; VL SUBRAHMANYAM, Lanka; PREM KUMAR, Mamnoor
Patent: WO2011/61590 A1, 2011 ;
Location in patent: Page/Page column 39 ;

160232-08-6[(1S,2R)-2-羟基-3-[(2-甲基丙基)氨基]-1-(苯基甲基)丙基]-1,1,-二甲基乙酯

参考文献

Vellanki, Siva Rama Prasad; Sahu, Arabinda; Katukuri, Aravind Kumar; Vanama, Vikram; Kothari, Satishbabu; Ponnekanti, Venkata Suryanarayana; Datta, Debashish
Patent: US2012/251826 A1, 2012 ;
Location in patent: Page/Page column 9-10 ;