1: t-butyl 2-(diethoxyphosphoryl)acetate With methylmagnesium bromide in tetrahydrofuran; diethyl ether
T=20°C; Wadsworth-Emmons reaction; 0.25 h; Inert atmosphere;
2: isobutyraldehyde in tetrahydrofuran; diethyl ether
Wadsworth-Emmons reaction; RefluxInert atmosphere; diastereoselective reaction;
参考文献
Claridge, Timothy D. W.; Davies, Stephen G.; Lee, James A.; Nicholson, Rebecca L.; Roberts, Paul M.; Russell, Angela J.; Smith, Andrew D.; Toms, Steven M.
Organic Letters, 2008 , vol. 10, # 23 p. 5437 - 5440
1: t-butyl 2-(diethoxyphosphoryl)acetate With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; Wadsworth-Emmons reaction; 0.5 h; Inert atmosphere;
2: isobutyraldehyde in tetrahydrofuran; hexane
T=-78 - 20°C; Wadsworth-Emmons reaction; Inert atmosphere; optical yield given as percent de;
参考文献
Claridge, Timothy D. W.; Davies, Stephen G.; Lee, James A.; Nicholson, Rebecca L.; Roberts, Paul M.; Russell, Angela J.; Smith, Andrew D.; Toms, Steven M.
Organic Letters, 2008 , vol. 10, # 23 p. 5437 - 5440
Durman, John; Elliott, Jason; McElroy, Andrew B.; Warren, Stuart
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1237 - 1244
