bromine; pyrrolidine formamide hydrochloride in tetrachloromethane
T=60 - 70°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Pews, R. Garth; Lysenko, Zenon
Synthetic Communications, 1985 , vol. 15, # 11 p. 977 - 984
1: ethyl acetoacetate With sodium hydroxide; 4-toluenesulfonyl azide; Tetrahexylammonium bromide in diethyl ether; water
T=20°C; 1.5 h;
2: isobutyraldehyde in diethyl ether; water
T=0°C; aldol reaction; 3 h; Further stages.;
