1: anhydrous cyanoacetic acid With potassium hydroxide in water T=5°C; 0.25 h; 2: isobutyraldehyde With hydrogen; 5 palladium on charcoal in water P=750.075 Torr; 17 h; 3: With hydrogenchloride in water T=5°C; 0.25 h;
参考文献
PFIZER MANUFACTURING IRELAND; BURRELL, Adam James Musgrave; MARTINEZ, Carlos Alberto; MCDAID, Paul Oliver; O'NEILL, Padraig Mary; WONG, John Wing
Patent: WO2012/25861 A1, 2012 ;
Location in patent: Page/Page column 23-24 ;
WO 2012/025861 A1