2,7,7-三甲基-5-氧代-4-[2-(三氟甲基)苯基]-1,4,6,8-四氢喹啉-3-羧酸乙酯合成路线 （共 2 条）
反应条件
1: ethyl acetoacetate; dimedone With ytterbium(III) triflate in acetonitrile
Hantzsch pyridine synthesis; 0.166667 h; Inert atmosphere;
2: α,α,α-trifluoro-o-tolualdehyde With ammonium acetate in acetonitrile
T=20°C; Hantzsch pyridine synthesis;
参考文献
Evans, Christopher G.; Jinwal, Umesh K.; Makley, Leah N.; Dickey, Chad A.; Gestwicki, Jason E.
Chemical Communications, 2011 , vol. 47, # 1 p. 529 - 531
反应条件
triethylamine in ethanol
2 h; Heating;
参考文献
Vitolinya, R. O.; Stankevich, E. I.; Grinshtein, E. E.; Dreimane, A. Ya.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 1 p. 17 - 19
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 1 p. 39 - 42
