(3,4-二甲氧基苄基)-磷酸二乙酯合成路线 （共 5 条）
反应条件
sodium methylate 1.) DMF, 0 deg C, 30 min, 2.) a) DMF, from 0 deg C to RT, 1.5 h, b) 95-100 deg C, 1 h, c) RT, overnight; Multistep reaction;
参考文献
Cushman, Mark; Nagarathnam, Dhanapalan; Gopal, D.; Chakraborti, Asit K.; Lin, Chii M.; Hamel, Ernest
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2579 - 2588
反应条件
tetra-(n-butyl)ammonium iodide
T=110°C; 24 h;
参考文献
Koufaki, Maria; Theodorou, Elissavet; Galaris, Dimitrios; Nousis, Lambros; Katsanou, Efrosini S.; Alexis, Michael N.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 300 - 306
反应条件
1: 85 percent / PBr3
2: 90 percent / (nBu)4NI
View Scheme
参考文献
Hirano; Osawa; Yamaoka; Yokoi
Biological and Pharmaceutical Bulletin, 2001 , vol. 24, # 11 p. 1277 - 1281
参考文献
Fresneda, P.M.; Molina, P.
Synthesis, 1981 , # 3 p. 222 - 223
反应条件
T=130°C; Michaelis-Arbuzov Synthesis; 24 h; Inert atmosphere;
参考文献
Mikstacka, Renata; Wierzchowski, Marcin; Dutkiewicz, Zbigniew; Gielara-Korzanska, Agnieszka; Korzanski, Artur; Teubert, Anna; Sobiak, Stanislaw; Baer-Dubowska, Wanda
MedChemComm, 2014 , vol. 5, # 4 p. 496 - 501
