4,5-二氟-2-硝基苯胺合成路线 （共 13 条）
反应条件
ammonia in methanol T=70°C; 1.5 h; Microwave irradiation;
参考文献
SCIFLUOR LIFE SCIENCES, LLC; Duggan, Mark E.; Furuya, Takeru; Edwards, D. Scott; Purohit, Ajay
Patent: US2013/287686 A1, 2013 ;
Location in patent: Paragraph 0144; 0145 ;
反应条件
nitric acid in acetic acid T=90°C; 4 h;
参考文献
Leyva, Socorro; Castanedo, Victor; Leyva, Elisa
Journal of Fluorine Chemistry, 2003 , vol. 121, # 2 p. 171 - 175
反应条件
hydrogenchloride in ethanol T=20°C; 2 h; Heating / reflux;
参考文献
WO2005/123737 A2, ;
Page/Page column 119 ;
反应条件
hydrogenchloride in ethanol 3 h; Heating;
参考文献
El-Abadelah, Mustafa M.; Nazer, Musa Z.; El-Abadla, Naser S.; Meier, Herbert
Heterocycles, 1995 , vol. 41, # 10 p. 2203 - 2220
反应条件
1: aq. HCl / 90 °C 2: 24 percent / HNO3 / acetic acid / 4 h / 90 °C View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 121, # 2 p. 171 - 175
反应条件
1: 97 percent 2: 80 percent / H2 / PtO2 View Scheme
参考文献
Konstantinova, Irina D.; Selezneva, Olga M.; Fateev, Ilja V.; Balashova, Tamara A.; Kotovskaya, Svetlana K.; Baskakova, Zoya M.; Charushin, Valery N.; Baranovsky, Alexander V.; Miroshnikov, Anatoly I.; Balzarini, Jan; Mikhailopulo, Igor A.
Synthesis (Germany), 2013 , vol. 45, # 2 art. no. SS-2012-T0784-OP, p. 272 - 280
反应条件
1: NH2NH2•xH2O / ethanol / |Reflux 2: |Reflux View Scheme
参考文献
Synthesis (Germany), , vol. 45, # 2 art. no. SS-2012-T0784-OP, p. 272 - 280
反应条件
hydrogenchloride; tin(ll) chloride
参考文献
Baudy, Reinhardt B.; Greenblatt, Lynne P.; Jirkovsky, Ivo L.; Conklin, Mary; Russo, Ralph J.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 331 - 342
反应条件
hydrogenchloride in methanol
参考文献
The Regents of the University of Michigan
Patent: US5360795 A1, 1994 ;
反应条件
sodium hydroxide T=20°C; 1 h;
参考文献
Konstantinova, Irina D.; Selezneva, Olga M.; Fateev, Ilja V.; Balashova, Tamara A.; Kotovskaya, Svetlana K.; Baskakova, Zoya M.; Charushin, Valery N.; Baranovsky, Alexander V.; Miroshnikov, Anatoly I.; Balzarini, Jan; Mikhailopulo, Igor A.
Synthesis (Germany), 2013 , vol. 45, # 2 art. no. SS-2012-T0784-OP, p. 272 - 280
