4,5-二氟-2-硝基苯胺合成路线 （共 13 条）
反应条件
1: With sulfuric acid; sodium nitrite in acetic acid T=0°C; 1 h; 2: With sodium azide in water 3: With acetic acid 2 h; Heating;
参考文献
Carta, Antonio; Paglietti, Giuseppe; Rahbar Nikookar, Mohammad E; Sanna, Paolo; Sechi, Leonardo; Zanetti, Stefania
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 5 p. 355 - 366
反应条件
1: 95 percent 2: 75 percent / NH2NH2 / 10 percent Pd/C / ethanol View Scheme
参考文献
Konstantinova, Irina D.; Selezneva, Olga M.; Fateev, Ilja V.; Balashova, Tamara A.; Kotovskaya, Svetlana K.; Baskakova, Zoya M.; Charushin, Valery N.; Baranovsky, Alexander V.; Miroshnikov, Anatoly I.; Balzarini, Jan; Mikhailopulo, Igor A.
Synthesis (Germany), 2013 , vol. 45, # 2 art. no. SS-2012-T0784-OP, p. 272 - 280
反应条件
1: 4,5-difluoro-2-nitro-phenylamine With hydrogen; palladium 10 on activated carbon in methanol
T=20°C; 3 h;
2: 2,2-diethoxy-ethanimidic acid methyl ester With acetic acid in methanol
T=20°C; 16 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/12623 A1, 2008 ;
Location in patent: Page/Page column 56 ;
WO 2008/012623 A1
