2-(1-苄基-4-哌啶)乙腈合成路线 （共 12 条）
反应条件
T=140°C; Alkylation; 20 h;
参考文献
Mayer; Brunel; Chaplain; Piedecoq; Calmel; Schambel; Chopin; Wurch; Pauwels; Marien; Vidaluc; Imbert
Journal of Medicinal Chemistry, 2000 , vol. 43, # 20 p. 3653 - 3664
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 7 p. 1880 - 1887
反应条件
sodium hydroxide in ethanol 28 h; Heating;
参考文献
Contreras; Parrot; Sippl; Rival; Wermuth
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2707 - 2718
反应条件
1: With magnesium in methanol
T=5 - 10°C; 4 h;
2: With hydrogenchloride in methanol; water
3: With sodium hydroxide in methanol; water
参考文献
PIRAMAL LIFE SCIENCES LIMITED; SIVAKUMAR, Meenakshi; JOSHI, Kalpana Sanjay; AWARE, Valmik Sopan; SARDE, Ankush Gangaram; BAGUL, Sandeep Mukunda; MANOHAR, Sonal Mohan
Patent: WO2011/104680 A1, 2011 ;
Location in patent: Page/Page column 78 ;
WO 2011/104680 A1
反应条件
1: 90.3 percent / CH2Cl2 / 20 °C
2: 85.5 percent / NaBH4; HCl
3: aq. NaOH
4: dimethylformamide / Heating
View Scheme
参考文献
Shao, Dong; Zou, Chunyan; Luo, Cheng; Tang, Xican; Li, Yuanchao
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 18 p. 4639 - 4642
反应条件
hydrogenchloride; sodium hydroxide in N,N-dimethyl-formamide
Reflux;
参考文献
Asadipour, Ali; Alipour, Masoumeh; Jafari, Mona; Khoobi, Mehdi; Emami, Saeed; Nadri, Hamid; Sakhteman, Amirhossein; Moradi, Alireza; Sheibani, Vahid; Homayouni Moghadam, Farshad; Shafiee, Abbas; Foroumadi, Alireza
European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 623 - 630
反应条件
1: 85.5 percent / NaBH4; HCl
2: aq. NaOH
3: dimethylformamide / Heating
View Scheme
参考文献
Shao, Dong; Zou, Chunyan; Luo, Cheng; Tang, Xican; Li, Yuanchao
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 18 p. 4639 - 4642
反应条件
1: aq. NaOH
2: dimethylformamide / Heating
View Scheme
参考文献
Shao, Dong; Zou, Chunyan; Luo, Cheng; Tang, Xican; Li, Yuanchao
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 18 p. 4639 - 4642
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 14 h / 65 °C
2.1: potassium carbonate / tetrahydrofuran / 0.58 h / 20 °C / Reflux
2.2: 16 h / 70 °C
3.1: magnesium / methanol / 4 h / 5 - 10 °C
View Scheme
参考文献
PIRAMAL LIFE SCIENCES LIMITED; SIVAKUMAR, Meenakshi; JOSHI, Kalpana Sanjay; AWARE, Valmik Sopan; SARDE, Ankush Gangaram; BAGUL, Sandeep Mukunda; MANOHAR, Sonal Mohan
Patent: WO2011/104680 A1, 2011 ;
WO 2011/104680 A1
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 14 h / 65 °C
2.1: potassium carbonate / tetrahydrofuran / 0.58 h / 20 °C / Reflux
2.2: 16 h / 70 °C
3.1: magnesium / methanol / 4 h / 5 - 10 °C
View Scheme
参考文献
PIRAMAL LIFE SCIENCES LIMITED; SIVAKUMAR, Meenakshi; JOSHI, Kalpana Sanjay; AWARE, Valmik Sopan; SARDE, Ankush Gangaram; BAGUL, Sandeep Mukunda; MANOHAR, Sonal Mohan
Patent: WO2011/104680 A1, 2011 ;
WO 2011/104680 A1
