N-Boc-L-2-哌啶甲酰胺合成路线 （共 4 条）
反应条件
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia in DMF (N,N-dimethyl-formamide) 5 h;
参考文献
Chu, Shao Song; Alegria, Larry Andrew; Bleckman, Ted Michael; Chong, Wesley Kwan Mung; Duvadie, Rohit K.; Li, Lin; Reich, Siegfried Heinz; Romines III, William Henry; Wallace, Michael B.; Yang, Yi
Patent: US2003/225147 A1, 2003 ;
Location in patent: Page 29 ;
反应条件
ammonium hydroxide; triethylamine in tetrahydrofuran
反应条件
triethylamine; trifluoroacetic anhydride in tetrahydrofuran T=0 - 20°C; 18 h; Inert atmosphere;
参考文献
Barker, Graeme; Alshawish, Madeha R.; Skilbeck, Melanie C.; Coldham, Iain
Angewandte Chemie - International Edition, 2013 , vol. 52, # 30 p. 7700 - 7703
Angew. Chem., 2013 , vol. 125, # 30 p. 7854 - 7857,4
反应条件
hydrogenchloride in 1,4-dioxane
0.75 h; Ambient temperature;
参考文献
Johnson, Rodney L.; Rajakumar, G.; Mishra, Ram K.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 2100 - 2104
