6-氯-2-哌嗪-1-喹啉合成路线 （共 5 条）
反应条件
hydrogenchloride in methanol
T=20°C; 1 h;
参考文献
Merial Limited; Meng, Charles Q.; Long, Alan; Huber, Scot; Gurrala, Srinivas Reddy; Wilkinson, Douglas Edward; Pacofsky, Gregory
Patent: US2014/142114 A1, 2014 ;
Location in patent: Paragraph 0458 ;
反应条件
1: dimethylformamide / 80 °C
2: 4 M aq. H2SO4 / 80 °C
View Scheme
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Byung Chul; Chi, Dae Yoon; Choe, Yearn Seong; Jeong, Kyung Ja; Jin, Changbae
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1559 - 1562
反应条件
sulfuric acid
T=80°C; decarbonylation;
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Byung Chul; Chi, Dae Yoon; Choe, Yearn Seong; Jeong, Kyung Ja; Jin, Changbae
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1559 - 1562
反应条件
1: 55 percent / aq. NaClO3; HCl; AcOH / 0.33 h / 20 °C
2: POCl3; DDQ / dimethylformamide / 6 h / 20 °C
3: dimethylformamide / 80 °C
4: 4 M aq. H2SO4 / 80 °C
View Scheme
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Byung Chul; Chi, Dae Yoon; Choe, Yearn Seong; Jeong, Kyung Ja; Jin, Changbae
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1559 - 1562
反应条件
1: POCl3; DDQ / dimethylformamide / 6 h / 20 °C
2: dimethylformamide / 80 °C
3: 4 M aq. H2SO4 / 80 °C
View Scheme
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Byung Chul; Chi, Dae Yoon; Choe, Yearn Seong; Jeong, Kyung Ja; Jin, Changbae
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1559 - 1562
