4-溴-噻吩-3-羧酸甲酯合成路线 （共 9 条）
反应条件
1: 3,4-Dibromo-thiophene With isopropylmagnesium chloride in tetrahydrofuran T=0 - 5°C; 3 h; 2: methyl chloroformate in tetrahydrofuran T=20°C; 16 h;
参考文献
US2011/230495 A1, ;
Page/Page column 35-36 ;
反应条件
1: 4-bromothiophene-3-carboxylic acid With thionyl chloride 0.25 h; Heating; 2: methanol 1 h; Heating;
参考文献
Goerlitzer; Gabriel; Jomaa; Wiesner
Pharmazie, 2006 , vol. 61, # 11 p. 901 - 907
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite 1.) water, 0 deg C, 1 h, 2.) water, 60 deg C; Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 23, # 6 p. 1431 - 1435
反应条件
1: SOCl2 / 0.25 h / Heating 2: 1 h / Heating View Scheme
参考文献
Archiv der Pharmazie, , vol. 331, # 12 p. 405 - 411
反应条件
n-butyllithium 1.) Et2O, hexane, -116 deg C, 5 min, 2.) 20 deg C, 20 min; Yield givenMultistep reaction. Yields of byproduct given;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 2 p. 297 - 308
反应条件
1 h; Heating; Yield given;
参考文献
Archiv der Pharmazie, , vol. 331, # 12 p. 405 - 411
反应条件
1: 4-Bromthiophen-3-carbonsaeuremethylester; sodium methylate With sodium iodide; copper(II) oxide in methanol 68 h; Heating; 2: diazomethane in diethyl ether T=0°C;
参考文献
Mitsumori, Susumu; Tsuri, Tatsuo; Honma, Tsunetoshi; Hiramatsu, Yoshiharu; Okada, Toshihiko; Hashizume, Hiroshi; Inagaki, Masanao; Arimura, Akinori; Yasui, Kiyoshi; Asanuma, Fujio; Kishino, Junji; Ohtani, Mitsuaki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2446 - 2455
反应条件
1.1: CuO; NaI / methanol / 68 h / Heating 1.2: 83 percent / diethyl ether / 0 °C 2.1: 81 percent / aq. NaOH / methanol / 0.25 h / Heating View Scheme
参考文献
Mitsumori, Susumu; Tsuri, Tatsuo; Honma, Tsunetoshi; Hiramatsu, Yoshiharu; Okada, Toshihiko; Hashizume, Hiroshi; Inagaki, Masanao; Arimura, Akinori; Yasui, Kiyoshi; Asanuma, Fujio; Kishino, Junji; Ohtani, Mitsuaki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2446 - 2455
反应条件
sodium hydroxide in ethanol 0.5 h; Heating;
参考文献
Corral, Carlos; Lasso, Ana; Lissavetzky, Jaime; Alvarez-Insua, Alberto Sanchez; Valdeolmillos, Ana M.
Heterocycles, 1985 , vol. 23, # 6 p. 1431 - 1435
