2-氟-5-(1H-咪唑-5-基)吡啶合成路线 （共 2 条）
反应条件
hydrogenchloride in ethanol
1.5 h; Heating;
参考文献
Burger, Matthew T.; Lin, Xiaodong; Chu, Daniel T.; Hiebert, Christy; Rico, Alice C.; Seid, Mehran; Carroll, Georgia L.; Barker, Lynn; Huh, Kay; Langhorne, Mike; Shawar, Ribhi; Kidney, Jolene; Young, Kelly; Anderson, Scott; Desai, Manoj C.; Plattner, Jacob J.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1730 - 1743
反应条件
1.1: EtMgBr / tetrahydrofuran / 1.5 h / 20 °C
1.2: ZnCl2 / tetrahydrofuran / 1.5 h / 20 °C
1.3: 69 percent / tetrakis(triphenylphosphine)palladium / tetrahydrofuran / Heating
2.1: 46 percent / aq. HCl / ethanol / 1.5 h / Heating
View Scheme
参考文献
Burger, Matthew T.; Lin, Xiaodong; Chu, Daniel T.; Hiebert, Christy; Rico, Alice C.; Seid, Mehran; Carroll, Georgia L.; Barker, Lynn; Huh, Kay; Langhorne, Mike; Shawar, Ribhi; Kidney, Jolene; Young, Kelly; Anderson, Scott; Desai, Manoj C.; Plattner, Jacob J.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1730 - 1743
