1-(4-氟苯基)-2-哌嗪酮合成路线 (共 3 条)
反应条件
hydrogenchloride in 1,4-dioxane; dichloromethane T=0 - 25°C; 3 h;
参考文献
LUPIN LIMITED; JANA, Gourhari; KURHADE, Sanjay, Pralhad; JAGDALE, Arun, Rangnath; KUKREJA, Gagan; SINHA, Neelima; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar
Patent: WO2014/9872 A1, 2014 ;
Location in patent: Page/Page column 64 ;
反应条件
potassium phosphate; copper(l) iodide; cis-N,N'-dimethyl-1,2-diaminocyclohexane in 1,4-dioxane T=110°C; 24 h; Heating / reflux;
参考文献
WO2009/53459 A1, ;
Page/Page column 42 ;
WO 2009/053459 A1
反应条件
1: N,N-dimethylethylenediamine; potassium hydrophosphate; copper(l) iodide / toluene / 16 h / 25 - 80 °C 2: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 0 - 25 °C View Scheme