2-对硝基苯甲基-4,6-二氯-5-嘧啶乙酸甲酯合成路线 （共 3 条）
反应条件
triethylamine; trichlorophosphate in toluene
T=15 - 105°C; 3.08333 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; RODRIGUEZ DEHLI, Juan M.; HAGENKOETTER, Robert; SCHUL, Michael; STANGE, Christian; WANG, Xiao-Jun; ZHANG, Li; MASSOT, Oriol
Patent: WO2012/156221 A1, 2012 ;
Location in patent: Page/Page column 14 ;
反应条件
1.1: hydrogenchloride / 1,4-dioxane; ethanol / 22 h / 20 °C
1.2: 3 h
2.1: sodium methylate / methanol / 3 h / Reflux
2.2: 0 °C
3.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 3 h / Reflux
View Scheme
参考文献
Ly, Tai Wei
Patent: US2011/172250 A1, 2011 ;
US 20110172250 A1
反应条件
1.1: sodium methylate / methanol / 3 h / Reflux
1.2: 0 °C
2.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 3 h / Reflux
View Scheme
参考文献
Ly, Tai Wei
Patent: US2011/172250 A1, 2011 ;
US 20110172250 A1
