1-(2-羟基乙氧基甲基)-5-三氟甲基-1H-嘧啶-2,4-二酮合成路线 （共 3 条）
反应条件
sodium methylate in methanol
0.5 h; Heating;
参考文献
Kelley, James L.; Kelsey, John E.; Hall, William R.; Krochmal, Mark P.; Schaeffer, Howard J.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 753 - 756
反应条件
1: acetonitrile / 20 °C
2: 320 mg / KI; chlorotrimethylsilane / 16 h / 25 °C
View Scheme
参考文献
Semaine, Wassila; Johar, Monika; Tyrrell, D. Lorne J.; Kumar, Rakesh; Agrawal
Journal of Medicinal Chemistry, 2006 , vol. 49, # 6 p. 2049 - 2054
反应条件
chloro-trimethyl-silane; potassium iodide
T=25°C; 16 h;
参考文献
Semaine, Wassila; Johar, Monika; Tyrrell, D. Lorne J.; Kumar, Rakesh; Agrawal
Journal of Medicinal Chemistry, 2006 , vol. 49, # 6 p. 2049 - 2054
