1-甲基-4-(3-甲基丁-3-烯氧基磺酰基)苯合成路线 （共 20 条）
反应条件
1.1: sodium hydride; potassium iodide / tetrahydrofuran; mineral oil / 0.25 h / 20 - 70 °C / Inert atmosphere 1.2: 20.08 h / 70 °C / Inert atmosphere 2.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 40 h / 20 °C 2.2: 0 °C / pH 3 3.1: copper(I) oxide / acetonitrile / 20 h / 85 °C / Inert atmosphere 3.2: 0 °C / Inert atmosphere View Scheme
参考文献
Ghosh, Arun K.; Nicponski, Daniel R.
Organic Letters, 2011 , vol. 13, # 16 p. 4328 - 4331
反应条件
lithium bromide in N,N-dimethyl-formamide T=20°C; Substitution; 24 h;
参考文献
Braddock, D. Christopher; Brown, John M.
Collection of Czechoslovak Chemical Communications, 2000 , vol. 65, # 5 p. 741 - 756
反应条件
1.1: 72 percent / NaI / acetone / 2 h / Heating 2.1: LDA / tetrahydrofuran; hexane 2.2: 62 percent / tetrahydrofuran; hexane 3.1: 74 percent / aq. AcOH / 2 h / 20 °C 4.1: 38 percent / Me2AlCl / hexane / 24 h / -78 - 20 °C View Scheme
参考文献
Braddock, D. Christopher; Brown, John M.
Collection of Czechoslovak Chemical Communications, 2000 , vol. 65, # 5 p. 741 - 756
反应条件
2: 62 percent View Scheme
参考文献
Badet,B.; Julia,M.; Mallet,J.M.
Tetrahedron, 1988 , vol. 44, p. 2913
反应条件
1: 85 percent / NaH / tetrahydrofuran 2: 78 percent / [RhCl(cis-cyclooctene)2]2; tricyclohexylphosphonium chloride / 1,2-dichloro-benzene; acetone / 0.1 h / 225 °C / microwave irradiation View Scheme
参考文献
Tan; Bergman; Ellman
Journal of the American Chemical Society, 2001 , vol. 123, # 11 p. 2685 - 2686
反应条件
pyridine
T=0°C; 2.5 h;
参考文献
Piron, Karel; Verniest, Guido; Van Hende, Eva; De Kimpe, Norbert
Arkivoc, 2012 , vol. 2012, # 5 p. 6 - 15
反应条件
1: tetrabutylammonium fluoride / tetrahydrofuran / 20 °C
2: 1.09 g / calcium hydride; N,N-dimethyl-4-aminopyridine / CH2Cl2 / 20 °C
View Scheme
参考文献
Kao, Chai-Lin; Kittleman, William; Zhang, Hua; Seto, Haruo; Liu, Hung-Wen
Organic Letters, 2005 , vol. 7, # 25 p. 5677 - 5680
反应条件
1: lithium aluminium hydride
2: pyridine
View Scheme
参考文献
Lombardo, Domenic A.; Weedon, Alan C.
Tetrahedron Letters, 1986 , vol. 27, # 46 p. 5555 - 5558
反应条件
method of Brandsma (ref. 9);
参考文献
Atkinson, Robert S.; Grimshire, Michael J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1135 - 1146
反应条件
1: 15 percent
2: NaH
3: dimethyl copper lithium
View Scheme
参考文献
Lombardo, Domenic A.; Weedon, Alan C.
Tetrahedron Letters, 1986 , vol. 27, # 46 p. 5555 - 5558
