1: 1) KH, 2) n-BuLi / tetrahydrofuran / 1) 30 min, 2) Hexane, 30 min
2: 2.53 g / tetrahydrofuran / 24 h / Ambient temperature
View Scheme
参考文献
Trimitsis, G. B.; Hinkley, J. M.; TenBrink, R.; Faburada, A. L.; Anderson, R.; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 18 p. 2957 - 2962
1: With sulfuric acid; sodium lauryl sulfate in water
T=60°C;
2: With iodine in water
T=60°C;
3: With sodium nitrite in water
T=60°C; regioselective reaction;
参考文献
Stavber, Gaj; Iskra, Jernej; Zupan, Marko; Stavber, Stojan
Green Chemistry, 2009 , vol. 11, # 8 p. 1262 - 1267
1: 1) KH, 2) n-BuLi / tetrahydrofuran / 1) 30 min, 2) Hexane, 30 min
2: 1.61 g / tetrahydrofuran / 24 h / Ambient temperature; var. alkyl halides, C-1/C-3 ratio of alkylated products
View Scheme
参考文献
Trimitsis, G. B.; Hinkley, J. M.; TenBrink, R.; Faburada, A. L.; Anderson, R.; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 18 p. 2957 - 2962
1: 1) KH, 2) n-BuLi / tetrahydrofuran / 1) 30 min, 2) Hexane, 30 min
2: 2.45 g / tetrahydrofuran / 24 h / Ambient temperature
View Scheme
参考文献
Trimitsis, G. B.; Hinkley, J. M.; TenBrink, R.; Faburada, A. L.; Anderson, R.; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 18 p. 2957 - 2962
