7-硝基-3-氧代-3,4-二氢-喹噁啉e-2-羧酸乙酯合成路线 (共 2 条)
反应条件
1: 7-nitro-3-oxo-3,4-dihydro-quinoxaline-2-carboxylic acid With thionyl chloride in toluene
2 h; Heating / reflux;
2: ethanol in toluene
Heating / reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/56547 A2, 2005 ;
Location in patent: Page/Page column 49 ;
WO 2005/056547 A2
反应条件
1: T=20°C; under vacuum;
2: aerial oxidative aromatization; Further stages.;
参考文献
Haldar, Pranab; Dutta, Bishnupada; Guin, Joyram; Ray, Jayanta K.
Tetrahedron Letters, 2007 , vol. 48, # 33 p. 5855 - 5857