(2-氨基苯甲基)三苯基溴化膦合成路线 （共 27 条）
反应条件
1: CH2Cl2 / 4 h 2: 80.9 percent / sodium tert-pentylate / toluene / 3 h / Heating 3: 39.3 percent / CF3COOH / CH2Cl2 / 1.) 0 deg C, 2.5 h, 2.) r.t., 15 h 4: 98.2 percent / hydrogen / tris(triphenylphosphine)rhodium(I) chloride / benzene / 18 h / 55 °C / 7500.6 Torr View Scheme
参考文献
Freund; Martinovic; Bernauer
Helvetica Chimica Acta, 1992 , vol. 75, # 1 p. 282 - 287
反应条件
1: 93 percent / CH2Cl2 / 3 h 2: 5 percent / KOtBu / toluene / Heating View Scheme
参考文献
Capuano, Lilly; Ahlhelm, Alfred; Hartmann, Herbert
Chemische Berichte, 1986 , vol. 119, # 6 p. 2069 - 2074
反应条件
1: 91 percent / CH2Cl2 / 3 h 2: 50 percent / KOtBu / toluene / 0.25 h / Heating View Scheme
参考文献
Capuano, Lilly; Ahlhelm, Alfred; Hartmann, Herbert
Chemische Berichte, 1986 , vol. 119, # 6 p. 2069 - 2074
反应条件
1: NEt3 / CH2Cl2; toluene 2: 96 percent / MeONa / toluene / Heating View Scheme
参考文献
Corre, M. Le; Hercouet, A.; Stanc, Y. Le; Baron, H. Le
Tetrahedron, 1985 , vol. 41, # 22 p. 5313 - 5320
反应条件
1: With acetic acid in methanol T=80°C; 0.166667 h; Inert atmosphereMicrowave irradiation; 2: With potassium tert-butylate in tetrahydrofuran T=25°C; 1 h; Inert atmosphere;
参考文献
Kraus, George A.; Guo, Haitao
Organic Letters, 2008 , vol. 10, # 14 p. 3061 - 3063
反应条件
1: NEt3 / CH2Cl2; toluene 2: 97 percent / MeONa / toluene / Heating View Scheme
参考文献
Corre, M. Le; Hercouet, A.; Stanc, Y. Le; Baron, H. Le
Tetrahedron, 1985 , vol. 41, # 22 p. 5313 - 5320
反应条件
1: 93 percent / CH2Cl2 / 3 h 2: 90 percent / KOtBu / toluene / Heating View Scheme
参考文献
Capuano, Lilly; Ahlhelm, Alfred; Hartmann, Herbert
Chemische Berichte, 1986 , vol. 119, # 6 p. 2069 - 2074
反应条件
1: 71 percent / CH2Cl2 / 3 h 2: 70 percent / t-BuOK / toluene / 0.25 h / Heating View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: With acetic acid in methanol T=80°C; 0.166667 h; Inert atmosphereMicrowave irradiation; 2: With potassium tert-butylate in tetrahydrofuran T=25°C; 1 h; Inert atmosphere;
参考文献
Kraus, George A.; Guo, Haitao
Organic Letters, 2008 , vol. 10, # 14 p. 3061 - 3063
反应条件
1: 87 percent / pyridine / CH2Cl2 / 0.5 h / Heating 2: 37 percent / t-BuOK / toluene / 0.67 h / Heating View Scheme
参考文献
Eitel, Manfred; Pindur, Ulf
Synthesis, 1989 , # 5 p. 364 - 367
