(2-氨基苯甲基)三苯基溴化膦合成路线 （共 27 条）
反应条件
1: 71 percent / CH2Cl2 / 3 h 2: 70 percent / t-BuOK / toluene / 0.25 h / Heating 3: 100 percent / DMAP / CH2Cl2 / 3 h / Ambient temperature View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
in acetonitrile
6 h; Heating;
参考文献
Hadida Ruah, Sara S.; Grootenhuis, Peter D.J.; Van Goor, Frederick; Zhou, Jinglan; Bear, Brian; Miller, Mark T.; McCartney, Jason; Numa, Mehdi Michel Jamel
Patent: US2007/244159 A1, 2007 ;
Location in patent: Page/Page column 132-133 ;
反应条件
hydrogen bromide; zinc in ethanol
参考文献
Corre, Maurice Le; Hercouet, Alain; Baron, Henri Le
Journal of the Chemical Society, Chemical Communications, 1981 , # 1 p. 14 - 15
反应条件
1: N-bromosuccinimide (NBS), peroxyde de benzoyle / CCl4
2: 69 percent / toluene / 1.) 3h, RT, 2.) 2h, reflux
3: 94 percent / 48percent HBr, Zn / ethanol / 2 h / Heating
View Scheme
参考文献
Corre, M. Le; Hercouet, A.; Stanc, Y. Le; Baron, H. Le
Tetrahedron, 1985 , vol. 41, # 22 p. 5313 - 5320
反应条件
1: 69 percent / toluene / 1.) 3h, RT, 2.) 2h, reflux
2: 94 percent / 48percent HBr, Zn / ethanol / 2 h / Heating
View Scheme
参考文献
Corre, M. Le; Hercouet, A.; Stanc, Y. Le; Baron, H. Le
Tetrahedron, 1985 , vol. 41, # 22 p. 5313 - 5320
反应条件
1: 90 percent / CH2Cl2 / 3 h
2: KOtBu / toluene / Heating
View Scheme
参考文献
Capuano, Lilly; Ahlhelm, Alfred; Hartmann, Herbert
Chemische Berichte, 1986 , vol. 119, # 6 p. 2069 - 2074
反应条件
1: CH2Cl2 / 4 h
2: 80.9 percent / sodium tert-pentylate / toluene / 3 h / Heating
View Scheme
参考文献
Freund; Martinovic; Bernauer
Helvetica Chimica Acta, 1992 , vol. 75, # 1 p. 282 - 287
反应条件
1: 81 percent / CH2Cl2 / 4 h
2: 72.2 percent / 1,95 N tert-pentylate / toluene / 3 h / Heating
View Scheme
参考文献
Mahboobi, Siavosh; Bernauer, Karl
Helvetica Chimica Acta, 1988 , vol. 71, p. 2034 - 2041
反应条件
1: 93 percent / pyridine / CH2Cl2 / 0.5 h / Heating
2: 38 percent / t-BuOK / toluene / 0.67 h / Heating
View Scheme
参考文献
Eitel, Manfred; Pindur, Ulf
Synthesis, 1989 , # 5 p. 364 - 367
反应条件
pyridine in dichloromethane
0.5 h; Heating;
参考文献
Corre, M. Le; Hercouet, A.; Stanc, Y. Le; Baron, H. Le
Tetrahedron, 1985 , vol. 41, # 22 p. 5313 - 5320
