4-(2-氨基吡啶-3-基氨基)哌啶-1-羧酸叔丁酯合成路线 （共 9 条）
反应条件
sodium tris(acetoxy)borohydride; trifluoroacetic acid in ethyl acetate T=20°C; 2 h;
参考文献
Leahy, David K.; Desai, Lopa V.; Deshpande, Rajendra P.; Mariadass, Antony V.; Rangaswamy, Sundaramurthy; Rajagopal, Santhosh K.; Madhavan, Lakshmi; Illendula, Shashidhar
Organic Process Research and Development, 2012 , vol. 16, # 2 p. 244 - 249
反应条件
1: With N-(diphenylmethylene)amine in toluene 0.5 h; Inert atmosphere; 2: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl T=95 - 100°C; 20 h; 3: With citric acid in ethanol; water T=55 - 60°C; 15 h; Large scale reaction;
参考文献
Leahy, David K.; Desai, Lopa V.; Deshpande, Rajendra P.; Mariadass, Antony V.; Rangaswamy, Sundaramurthy; Rajagopal, Santhosh K.; Madhavan, Lakshmi; Illendula, Shashidhar
Organic Process Research and Development, 2012 , vol. 16, # 2 p. 244 - 249
反应条件
sodium tris(acetoxy)borohydride; acetic acid in 1,2-dichloro-ethane T=20°C; 4 h;
参考文献
Organic Process Research and Development, , vol. 16, # 2 p. 244 - 249
反应条件
1.1: sodium tris(acetoxy)borohydride; trifluoroacetic acid / ethyl acetate / 2 h / 20 °C / Large scale reaction 2.1: N-(diphenylmethylene)amine / toluene / 0.5 h / Inert atmosphere 2.2: 20 h / 95 - 100 °C 2.3: 15 h / 55 - 60 °C / Large scale reaction View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 2 p. 244 - 249
反应条件
1.1: sodium tris(acetoxy)borohydride; trifluoroacetic acid / ethyl acetate / 2 h / 20 °C / Large scale reaction 2.1: N-(diphenylmethylene)amine / toluene / 0.5 h / Inert atmosphere 2.2: 20 h / 95 - 100 °C 2.3: 15 h / 55 - 60 °C / Large scale reaction View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 2 p. 244 - 249
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile T=0 - 20°C; 2.5 h;
参考文献
Leahy, David K.; Desai, Lopa V.; Deshpande, Rajendra P.; Mariadass, Antony V.; Rangaswamy, Sundaramurthy; Rajagopal, Santhosh K.; Madhavan, Lakshmi; Illendula, Shashidhar
Organic Process Research and Development, 2012 , vol. 16, # 2 p. 244 - 249
反应条件
1,1'-carbonyldiimidazole in acetonitrile T=20°C;
参考文献
MERCK and CO., INC.
Patent: WO2006/99268 A2, 2006 ;
Location in patent: Page/Page column 52-53 ;
WO 2006/099268 A2
反应条件
in acetonitrile T=20°C;
参考文献
MERCK and CO., INC.
Patent: WO2004/92166 A2, 2004 ;
Location in patent: Page 62 ;
WO 2004/092166 A2
反应条件
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2.5 h / 0 - 20 °C
2: hydrogenchloride / ethanol / 16 h / 50 - 55 °C
View Scheme
参考文献
Leahy, David K.; Desai, Lopa V.; Deshpande, Rajendra P.; Mariadass, Antony V.; Rangaswamy, Sundaramurthy; Rajagopal, Santhosh K.; Madhavan, Lakshmi; Illendula, Shashidhar
Organic Process Research and Development, 2012 , vol. 16, # 2 p. 244 - 249
