4-(2-氧代-2,3-二氢-1H-咪唑并[4,5-b]吡啶-1-基)哌啶-1-羧酸叔丁酯合成路线 （共 8 条）
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile T=0 - 20°C; 2.5 h;
参考文献
Leahy, David K.; Desai, Lopa V.; Deshpande, Rajendra P.; Mariadass, Antony V.; Rangaswamy, Sundaramurthy; Rajagopal, Santhosh K.; Madhavan, Lakshmi; Illendula, Shashidhar
Organic Process Research and Development, 2012 , vol. 16, # 2 p. 244 - 249
反应条件
1,1'-carbonyldiimidazole in acetonitrile T=20°C;
参考文献
WO2006/99268 A2, ;
Page/Page column 52-53 ;
WO 2006/099268 A2
反应条件
in acetonitrile T=20°C;
参考文献
WO2004/92166 A2, ;
Page 62 ;
WO 2004/092166 A2
反应条件
1.1: acetonitrile / 0.5 h / 20 °C 1.2: 0.83 h / 5 - 15 °C 1.3: 0.83 h / 5 °C 2.1: acetonitrile / 20 - 50 °C View Scheme
参考文献
WO2012/37226 A1, ;
WO 2012/037226 A1
反应条件
1.1: acetonitrile / 0.5 h / 20 °C 1.2: 0.83 h / 5 - 15 °C 1.3: 0.83 h / 5 °C 2.1: acetonitrile / 20 - 50 °C View Scheme
参考文献
WO2012/37226 A1, ;
WO 2012/037226 A1
反应条件
1.1: sodium tris(acetoxy)borohydride; trifluoroacetic acid / ethyl acetate / 2 h / 20 °C / Large scale reaction 2.1: N-(diphenylmethylene)amine / toluene / 0.5 h / Inert atmosphere 2.2: 20 h / 95 - 100 °C 2.3: 15 h / 55 - 60 °C / Large scale reaction 3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2.5 h / 0 - 20 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 2 p. 244 - 249
反应条件
1.1: N-(diphenylmethylene)amine / toluene / 0.5 h / Inert atmosphere 1.2: 20 h / 95 - 100 °C 1.3: 15 h / 55 - 60 °C / Large scale reaction 2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2.5 h / 0 - 20 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 2 p. 244 - 249
反应条件
hydrogenchloride in ethanol
T=50 - 55°C; 16 h;
参考文献
Leahy, David K.; Desai, Lopa V.; Deshpande, Rajendra P.; Mariadass, Antony V.; Rangaswamy, Sundaramurthy; Rajagopal, Santhosh K.; Madhavan, Lakshmi; Illendula, Shashidhar
Organic Process Research and Development, 2012 , vol. 16, # 2 p. 244 - 249
