hydrogen; palladium on activated charcoal in toluene P=760.051 Torr; 18 h;

hydrogen; palladium 10 on activated carbon in toluene P=760.051 Torr; 24 h;

hydrogen; palladium 10 on activated carbon in toluene P=760.051 Torr; 24 h;

1: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane 1 h; Alkaline aqueous solution; 2: With trifluoroacetic acid in dichloromethane 1 h; 3: With sodium hydrogencarbonate in dichloromethane; water

trifluoroacetic acid in dichloromethane 1.5 h;

1.1: dichloromethane; hexane; methanol / 1 h / 0 °C 1.2: 24 h / 20 °C 2.1: diisobutylaluminium hydride / toluene; diethyl ether / 0.58 h / -78 - -65 °C 2.2: 0.5 h / -65 - 20 °C 3.1: N,N,N',N'-tetramethylguanidine / toluene / 0.5 h / 0 °C 3.2: 1.5 h / 0 - 20 °C 4.1: 1,4-dioxane; water / 0.25 h / Inert atmosphere 4.2: 6 h / 20 - 35 °C 5.1: hydrogen / palladium 10 on activated carbon / ethanol / 36 h / 2844.39 Torr 6.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h View Scheme

1.1: 1,4-dioxane; water / 0.25 h / Inert atmosphere 1.2: 6 h / 20 - 35 °C 2.1: hydrogen / palladium 10 on activated carbon / ethanol / 36 h / 2844.39 Torr 3.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h View Scheme

1.1: diisobutylaluminium hydride / toluene; diethyl ether / 0.58 h / -78 - -65 °C 1.2: 0.5 h / -65 - 20 °C 2.1: N,N,N',N'-tetramethylguanidine / toluene / 0.5 h / 0 °C 2.2: 1.5 h / 0 - 20 °C 3.1: 1,4-dioxane; water / 0.25 h / Inert atmosphere 3.2: 6 h / 20 - 35 °C 4.1: hydrogen / palladium 10 on activated carbon / ethanol / 36 h / 2844.39 Torr 5.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h View Scheme

1.1: N,N,N',N'-tetramethylguanidine / toluene / 0.5 h / 0 °C 1.2: 1.5 h / 0 - 20 °C 2.1: 1,4-dioxane; water / 0.25 h / Inert atmosphere 2.2: 6 h / 20 - 35 °C 3.1: hydrogen / palladium 10 on activated carbon / ethanol / 36 h / 2844.39 Torr 4.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h View Scheme

1: hydrogen / palladium 10 on activated carbon / ethanol / 36 h / 2844.39 Torr 2: 1-hydroxy-7-aza-benzotriazole; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h View Scheme