N-甲氧基-N-甲基乙酰胺合成路线 （共 87 条）
反应条件
1: 4,5-dimethyl-thiazole With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2.16667 h; 2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; hexane T=-78°C; 2.16667 h; 3: With ammonium chloride in tetrahydrofuran; hexane; water 0.5 h;
参考文献
KIRIN BEER KABUSHIKI KAISHA
Patent: EP1535910 A1, 2005 ;
Location in patent: Page/Page column 25 ;
EP 1535910 A1
反应条件
1: 5-Bromo-2-chloropyridine With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=0°C; 0.25 h; Inert atmosphere; 2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
H. Lundbeck A/S; Eskildsen, Jørgen; Sams, Anette Graven; Püschl, Ask
Patent: US2013/12530 A1, 2013 ;
Location in patent: Paragraph 0187 ;
US 20130012530 A1
反应条件
in tetrahydrofuran; mineral oil; pentane T=-78 - 20°C;
参考文献
LeNaour, Morgan; Leclerc, Veronique; Farce, Amaury; Caignard, Daniel-Henri; Hennuyer, Nathalie; Staels, Bart; Audinot-Bouchez, Valerie; Boutin, Jean-Albert; Lonchampt, Michel; Dacquet, Catherine; Ktorza, Alain; Berthelot, Pascal; Lebegue, Nicolas
ChemMedChem, 2012 , vol. 7, # 12 p. 2179 - 2193
反应条件
1: 1,3-oxazole With isopropylmagnesium chloride in tetrahydrofuran T=-15 - -10°C; 1.16667 h; Inert atmosphere; 2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran T=-15 - 25°C; Inert atmosphere;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2009/77990 A1, 2009 ;
Location in patent: Page/Page column 94 ;
反应条件
1: 1,3-dibromo-5-(trifluoromethyl)benzene With n-butyllithium in hexane; di-isopropyl ether T=-78°C; 0.5 h; Inert atmosphere; 2: N,O-dimethylacetohydroxamic acid in hexane; di-isopropyl ether T=20°C; 0.5 h; Inert atmosphere;
参考文献
SAINT LOUIS UNIVERSITY; RUMINSKI, Peter; GRIGGS, David
Patent: WO2014/15054 A1, 2014 ;
Location in patent: Page/Page column 196 ;
反应条件
1: 5-bromo-pyrimidine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; hexane T=-78 - 0°C;
参考文献
EP2385035 A1, ;
Page/Page column 18-19 ;
反应条件
boron trifluoride diethyl etherate in 1,4-dioxane T=20 - 100°C; 1 h; Inert atmosphere;
参考文献
Bommegowda, Yadaganahalli K.; Lingaraju, Gejjalagere S.; Thamas, Saji; Vinay Kumar, Koravangala S.; Pradeepa Kumara, Challanayakanahally S.; Rangappa, Kanchugarakoppal S.; Sadashiva, Marilinganadoddi P.
Tetrahedron Letters, 2013 , vol. 54, # 21 p. 2693 - 2695
反应条件
1: 2-fluoro-pyridine With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 1 h; Inert atmosphere; 2: N,O-dimethylacetohydroxamic acid With hydrazine hydrate in tetrahydrofuran; hexane T=-78 - 60°C; 1 h; Inert atmosphere;
参考文献
TAIHO PHARMACEUTICAL CO., LTD.
Patent: US2012/108589 A1, 2012 ;
Location in patent: Page/Page column 14 ;
反应条件
1: 3-methyl thiophene With 2,2,6,6-tetramethyl-piperidine; isopropylmagnesium chloride in tetrahydrofuran T=66°C; Inert atmosphere; 2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran T=0°C; 18.5 h; Inert atmosphere; regioselective reaction;
参考文献
Asselin, Sylvie M.; Bio, Matthew M.; Langille, Neil F.; Ngai, Ka Yi
Organic Process Research and Development, 2010 , vol. 14, # 6 p. 1427 - 1431
参考文献
Reich, Siegfried Heinz; Wallace, Michael B.
Patent: US2002/6952 A1, 2002 ;
US 20020006952 A1
