N-甲氧基-N-甲基乙酰胺合成路线 （共 87 条）
反应条件
hydrogenchloride; magnesium in tetrahydrofuran; water; Petroleum ether
反应条件
1: pyridin-2-ylacetylene With n-butyllithium in tetrahydrofuran; hexane T=0°C; 0.25 h; 2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; hexane T=-78 - 20°C; 2.5 h; Further stages.;
参考文献
Schubert, Thomas; Hummel, Werner; Kula, Maria-Regina; Mueller, Michael
European Journal of Organic Chemistry, 2001 , # 22 p. 4181 - 4187
参考文献
Mitsui Chemicals, Inc.
Patent: US5932759 A1, 1999 ;
反应条件
1: triethyl-ethynyl-silane With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 0°C; 0.666667 h;
2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; hexane
T=-78 - -10°C;
参考文献
Trost, Barry M.; Fettes, Alec; Shireman, Brock T.
Journal of the American Chemical Society, 2004 , vol. 126, # 9 p. 2660 - 2661
反应条件
1: methyl acetylene With tert.-butyl lithium in tetrahydrofuran; pentane
T=-40°C;
2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; pentane
T=20°C; 1 h; Further stages.;
参考文献
Bos, Mary Ellen; Loncaric, Catherine; Wu, Chunrui; Wulff, William D.
Synthesis, 2006 , # 21 p. 3679 - 3705
反应条件
1: 1,2-dibromo-propane With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78 - 0°C;
2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; hexane
T=-78 - 20°C;
3: With hydrogenchloride in tetrahydrofuran; hexane; water
T=0°C;
参考文献
Tanaka, Yuta; Kanai, Motomu; Shibasaki, Masakatsu
Journal of the American Chemical Society, 2010 , vol. 132, # 26 p. 8862 - 8863
反应条件
1: 2-methylbenzonitrile With N,N'-dimethyl-N,N'-propyleneurea; lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78°C; Metallation; 0.25 h;
2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; hexane
T=-78°C; Acetylation; 0.5 h;
参考文献
Bunce, Richard A.; Johnson, Lara B.
Organic Preparations and Procedures International, 1999 , vol. 31, # 4 p. 407 - 412
反应条件
1: (3-bromophenyl)phenylmethane With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; hexane
T=-78 - 20°C; Further stages.;
参考文献
Zhuang, Linghang; Wai, John S.; Payne, Linda S.; Young, Steven D.; Fisher, Thorsten E.; Embrey, Mark W.; Guare, James P..
Patent: US2005/10048 A1, 2005 ;
Location in patent: Page/Page column 48 ;
反应条件
1: 4-methyl-thiazole With n-butyllithium in diethyl ether; pentane
T=-78°C; 1.5 h;
2: N,O-dimethylacetohydroxamic acid in diethyl ether; pentane
T=-78°C; 1.16667 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/87699 A2, 2004 ;
Location in patent: Page 60; 77 ;
WO 2004/087699 A2
反应条件
n-butyllithium in tetrahydrofuran; toluene
T=-60°C; 1 h; Inert atmosphere;
参考文献
SANOFI; SCHWINK, Lothar; BOSSART, Martin; GLOMBIK, Heiner; GOSSEL, Matthias; KADEREIT, Dieter; KLABUNDE, Thomas; MAIER, Thomas; STENGELIN, Siegfried
Patent: WO2014/56938 A1, 2014 ;
Location in patent: Page/Page column 68 ;
