N-甲氧基-N-甲基乙酰胺合成路线 （共 87 条）
反应条件
n-butyllithium in tetrahydrofuran
T=-78°C;
参考文献
Merck and Co., Inc.
Patent: US6642237 B1, 2003 ;
Location in patent: Page/Page column 135 ;
反应条件
1: 5-methyl thiazole With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 2.16667 h;
2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; hexane
T=-78°C; 2.16667 h;
3: With ammonium chloride in tetrahydrofuran; hexane; water
0.5 h;
参考文献
KIRIN BEER KABUSHIKI KAISHA
Patent: EP1535910 A1, 2005 ;
Location in patent: Page/Page column 24-25 ;
EP 1535910 A1
反应条件
1: 5-methyl thiazole With n-butyllithium in diethyl ether
T=-78°C; 0.25 h;
2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; diethyl ether
T=-78 - 20°C;
参考文献
Farmer, Luc J.; Bemis, Guy; Britt, Shawn D.; Cochran, John; Connors, Martin; Harrington, Edmund M.; Hoock, Thomas; Markland, William; Nanthakumar, Suganthini; Taslimi, Paul; Haar, Ernst Ter; Wang, Jian; Zhaveri, Darshana; Salituro, Francesco G.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6231 - 6235
反应条件
n-butyllithium; diisopropylamine
1.) THF, -5 deg C, 1.5 h, 2.) THF, 18 h; Yield givenMultistep reaction;
参考文献
Tawara, Jeanne N.; Lorenz, Peter; Stermitz, Frank R.
Journal of Natural Products, 1999 , vol. 62, # 2 p. 321 - 323
反应条件
1: 1-bromo-3-(propan-2-yl)benzene With n-butyllithium in tetrahydrofuran
T=-60°C; 0.5 h;
2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran
T=-30°C; 3 h;
参考文献
RIPKA, Amy S.; SAUNDERS, Jeffrey O.; KAMENECKA, Theodore Mark; GRIFFIN, Patrick R.
Patent: WO2013/78240 A1, 2013 ;
Location in patent: Page/Page column 57 ;
反应条件
1: propionic acid tert-butyl ester With n-butyllithium; diisopropylamine in diethyl ether
T=-78°C; 1 h; Inert atmosphere;
2: N,O-dimethylacetohydroxamic acid in diethyl ether
T=-78 - 20°C; Inert atmosphere;
3: With hydrogenchloride in diethyl ether; water
T=20°C; Inert atmosphere;
参考文献
Palomo, Claudio; Oiarbide, Mikel; Garcia, Jesus M.; Banuelos, Patricia; Odriozola, Jose M.; Razkin, Jesus; Linden, Anthony
Organic Letters, 2008 , vol. 10, # 13 p. 2637 - 2640
反应条件
1: 1-chloro-4-ethynylbenzene With n-butyllithium in tetrahydrofuran; hexane
T=0°C; 0.25 h;
2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; hexane
T=-78 - 20°C; 2.5 h; Further stages.;
参考文献
Schubert, Thomas; Hummel, Werner; Kula, Maria-Regina; Mueller, Michael
European Journal of Organic Chemistry, 2001 , # 22 p. 4181 - 4187
