5-异丙基吡唑-3-甲酸乙酯合成路线 （共 7 条）
反应条件
hydrazine monohydrochloride in tetrahydrofuran; ethanol; water T=75°C; 1 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 20 p. 5620 - 5623
反应条件
1: C8H16N2O2 With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 1 h; 2: oxalic acid diethyl ester in tetrahydrofuran; hexane T=-78 - 20°C; 16 h; 3: With toluene-4-sulfonic acid in toluene 8 h; Heating; Further stages.;
参考文献
Dang, Tung T.; Dang, Tuan T.; Fischer, Christine; Goerls, Helmar; Langer, Peter
Tetrahedron, 2008 , vol. 64, # 9 p. 2207 - 2215
反应条件
sulfuric acid 3 h; Heating / reflux;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2005/9965 A1, 2005 ;
Location in patent: Page/Page column 44-45 ;
WO 2005/009965 A1
反应条件
diethylamine in dimethyl sulfoxide T=20°C; 24 h; regioselective reaction;
参考文献
Chemistry - A European Journal, , vol. 19, # 23 p. 7555 - 7560
反应条件
1: With acetic anhydride in toluene T=150°C; 0.5 h; Inert atmosphereMicrowave irradiationsolid phase reaction; 2: With trifluoroacetic acid in dichloromethane T=20°C; 6 h; solid phase reaction;
参考文献
Organic Letters, , vol. 11, # 10 p. 2219 - 2221
反应条件
1: EtONa / ethanol / 18 h / 20 °C 2: N2H4*H2O; AcOH / 8 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 18 p. 3945 - 3951
反应条件
sodium hydroxide in 1,4-dioxane T=20°C; 18 h;
参考文献
Van Herk; Brussee; Van den Nieuwendijk; Van der Klein; IJzerman; Stannek; Burmeister; Lorenzen
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3945 - 3951
