3-甲氧基-5-硝基苯甲酸合成路线 （共 21 条）
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium methanolate 18 h; Ambient temperature;
参考文献
Herlt, Anthony J.; Kibby, Jeffrey J.; Rickards, Rodney W.
Australian Journal of Chemistry, 1981 , vol. 34, # 6 p. 1319 - 1324
反应条件
in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=20 - 80°C; 23 h; Inert atmosphere;
参考文献
Chamberland, Stephen; Grueschow, Sabine; Sherman, David H.; Williams, Robert M.
Organic Letters, 2009 , vol. 11, # 4 p. 791 - 794
反应条件
hydrogenchloride 0.5 h; Yield given;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 17, # 2 p. 313 - 317
Zhurnal Organicheskoi Khimii, , vol. 17, # 2 p. 369 - 374
反应条件
sodium hydroxide in water T=60 - 65°C; 0.5 h;
参考文献
Nekhoroshev, A. A.; Sevbo, D. P.; Ginzburg, O. A.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 2 p. 313 - 317
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 2 p. 369 - 374
反应条件
sodium hydroxide T=95°C; 1 h;
参考文献
Fujikura; Miigata; Hashimoto; Imai; Takenaka
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 11 p. 4092 - 4101
反应条件
1: 31 percent / MeOLi / 4 h / Heating 2: 98 percent / MeOLi, HMPT / 18 h / Ambient temperature View Scheme
参考文献
Australian Journal of Chemistry, , vol. 34, # 6 p. 1319 - 1324
反应条件
lithium methanolate 4 h; Heating;
参考文献
Australian Journal of Chemistry, , vol. 34, # 6 p. 1319 - 1324
反应条件
1: BH3 / tetrahydrofuran / 16 h / 0 - 25 °C 2: PDC; mol. sieves 4A / CH2Cl2 / 5 h / 25 °C View Scheme
参考文献
NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang
Patent: WO2013/148365 A1, 2013 ;
反应条件
1: 95 percent / AcOH; HBr / 20 h / Heating 2: 79 percent / NaBH4; I2 / tetrahydrofuran / 6 h / 20 °C View Scheme
参考文献
Hartung, Ingo V.; Rude, Mathew A.; Schnarr, Nathan A.; Hunziker, Daniel; Khosla, Chaitan
Journal of the American Chemical Society, 2005 , vol. 127, # 32 p. 11202 - 11203
反应条件
1: 84 percent / K2CO3 / acetone / 12 h / Heating 2: 76 percent / aq. NH4OH / methanol / 120 h / 20 °C View Scheme
参考文献
Yan, Zhiqing; Chang, Yuning; Mayo, Dennis; Maslak, Veselin; Xia, Shijing; Badjic, Jovica D.
Organic Letters, 2006 , vol. 8, # 17 p. 3697 - 3700
