3-甲氧基-5-硝基苯甲酸合成路线 （共 21 条）
反应条件
potassium carbonate in acetone 12 h; Heating;
参考文献
Yan, Zhiqing; Chang, Yuning; Mayo, Dennis; Maslak, Veselin; Xia, Shijing; Badjic, Jovica D.
Organic Letters, 2006 , vol. 8, # 17 p. 3697 - 3700
反应条件
in methanol; diphenylether T=0 - 5°C;
参考文献
Nekhoroshev, A. A.; Sevbo, D. P.; Ginzburg, O. A.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 2 p. 313 - 317
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 2 p. 369 - 374
反应条件
sodium hydroxide; nickel; hydrazine hydrate 1) water, 70 to 75 deg. C; 2) 70 to 80 deg. C, 30 min; Yield given. Multistep reaction;
参考文献
Nekhoroshev, A. A.; Sevbo, D. P.; Ginzburg, O. A.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 2 p. 313 - 317
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 2 p. 369 - 374
反应条件
hydrogen bromide; acetic acid 20 h; Heating;
参考文献
Hartung, Ingo V.; Rude, Mathew A.; Schnarr, Nathan A.; Hunziker, Daniel; Khosla, Chaitan
Journal of the American Chemical Society, 2005 , vol. 127, # 32 p. 11202 - 11203
反应条件
1.1: 84 percent / K2CO3 / acetone / 12 h / Heating 2.1: 76 percent / aq. NH4OH / methanol / 120 h / 20 °C 3.1: aq. NaOBr / methanol / 1.5 h / 20 °C 3.2: 84 percent / aq. NaHCO3 / 2 h / 80 °C View Scheme
参考文献
Yan, Zhiqing; Chang, Yuning; Mayo, Dennis; Maslak, Veselin; Xia, Shijing; Badjic, Jovica D.
Organic Letters, 2006 , vol. 8, # 17 p. 3697 - 3700
反应条件
hydrogen; palladium on activated charcoal
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2009/77385 A1, 2009 ;
Location in patent: Page/Page column 36 ;
WO 2009/077385 A1
反应条件
1: With diborane in tetrahydrofuran T=17 - 25°C; 6 h; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/40520 A1, 2006 ;
Location in patent: Page/Page column 144 ;
WO 2006/040520 A1
反应条件
1: 95 percent / AcOH; HBr / 20 h / Heating 2: 79 percent / NaBH4; I2 / tetrahydrofuran / 6 h / 20 °C 3: 75 percent / MnO2 / CH2Cl2; acetone / 24 h / 20 °C View Scheme
参考文献
Hartung, Ingo V.; Rude, Mathew A.; Schnarr, Nathan A.; Hunziker, Daniel; Khosla, Chaitan
Journal of the American Chemical Society, 2005 , vol. 127, # 32 p. 11202 - 11203
反应条件
thionyl chloride T=0°C; 6 h;
参考文献
JE IL PHARMACEUTICAL CO., LTD.
Patent: US2011/218193 A1, 2011 ;
Location in patent: Page/Page column 55 ;
US 20110218193 A1
反应条件
1: thionyl chloride / 6 h / 0 °C
2: hydrogen / palladium / ethyl acetate / 24 h / 20 °C
View Scheme
参考文献
JE IL PHARMACEUTICAL CO., LTD.
Patent: US2011/218193 A1, 2011 ;
US 20110218193 A1
