2-甲基-5-羟基色氨酸盐酸合成路线 （共 9 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol
T=26°C; P=2068.65 Torr; 2 h;
参考文献
HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian
Patent: WO2011/47156 A1, 2011 ;
Location in patent: Page/Page column 71 ;
WO 2011/047156 A1
反应条件
hydrogen; palladium on activated charcoal in ethanol
Ambient temperature;
参考文献
Ismaiel; Titeler; Miller; Smith; Glennon
Journal of medicinal chemistry, 1990 , vol. 33, # 2 p. 755 - 758
反应条件
1: diethyl ether / 1 h / 0 - 20 °C
2: conc. NH4OH / 4 h / Ambient temperature
3: LiAlH4 / tetrahydrofuran / 96 h / Heating
4: H2 / 10percent Pd/C / ethanol / Ambient temperature
View Scheme
参考文献
Ismaiel; Titeler; Miller; Smith; Glennon
Journal of medicinal chemistry, 1990 , vol. 33, # 2 p. 755 - 758
反应条件
1: conc. NH4OH / 4 h / Ambient temperature
2: LiAlH4 / tetrahydrofuran / 96 h / Heating
3: H2 / 10percent Pd/C / ethanol / Ambient temperature
View Scheme
参考文献
Ismaiel; Titeler; Miller; Smith; Glennon
Journal of medicinal chemistry, 1990 , vol. 33, # 2 p. 755 - 758
反应条件
1: trichlorophosphate / N,N-dimethyl-formamide
2: ammonium acetate
3: sodium tris(acetoxy)borohydride / tetrahydrofuran
4: palladium 10 on activated carbon; ammonium formate / methanol
View Scheme
参考文献
Baggett, Andrew W.; Cournia, Zoe; Han, Min Suk; Patargias, George; Glass, Adam C.; Liu, Shih-Yuan; Nolen, Brad J.
ChemMedChem, 2012 , vol. 7, # 7 p. 1286 - 1294
反应条件
1: ammonium acetate
2: sodium tris(acetoxy)borohydride / tetrahydrofuran
3: palladium 10 on activated carbon; ammonium formate / methanol
View Scheme
参考文献
Baggett, Andrew W.; Cournia, Zoe; Han, Min Suk; Patargias, George; Glass, Adam C.; Liu, Shih-Yuan; Nolen, Brad J.
ChemMedChem, 2012 , vol. 7, # 7 p. 1286 - 1294
反应条件
1: sodium tris(acetoxy)borohydride / tetrahydrofuran
2: palladium 10 on activated carbon; ammonium formate / methanol
View Scheme
参考文献
Baggett, Andrew W.; Cournia, Zoe; Han, Min Suk; Patargias, George; Glass, Adam C.; Liu, Shih-Yuan; Nolen, Brad J.
ChemMedChem, 2012 , vol. 7, # 7 p. 1286 - 1294
参考文献
Shaw
Journal of the American Chemical Society, 1955 , vol. 77, p. 4319,4320
Journal of the American Chemical Society, 1956 , vol. 78, p. 6419
反应条件
1: boron tribromide / dichloromethane / -70 - 0 °C
2: hydrogen / palladium 10 on activated carbon / methanol / 2 h / 26 °C / 2068.65 Torr
View Scheme
参考文献
HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian
Patent: WO2011/47156 A1, 2011 ;
WO 2011/047156 A1
