hydrogenchloride in various solvent(s) 0.5 h; Heating;

1: 96 percent / H2 / 10 percent Pd/C / ethanol / 19 h / 2585.7 Torr 2: 92 percent / 4 h / 140 - 145 °C 3: 1.) NaH / 1.) DMF, 50 deg C, 30 min, 2.) DMF, 50 deg C, 1 h 4: 81 percent / 6 N HCl / various solvent(s) / 0.5 h / Heating View Scheme

1: 1.) Na2S, NaOH, 2.) NaOH / 1.) H2O, from 52 deg C to 55 deg C, 2.5 h, 2.) H2O, reflux, 1 h 2: 92 percent / 4 h / 140 - 145 °C 3: 1.) NaH / 1.) DMF, 50 deg C, 30 min, 2.) DMF, 50 deg C, 1 h 4: 81 percent / 6 N HCl / various solvent(s) / 0.5 h / Heating View Scheme

1: 92 percent / 4 h / 140 - 145 °C 2: 1.) NaH / 1.) DMF, 50 deg C, 30 min, 2.) DMF, 50 deg C, 1 h 3: 81 percent / 6 N HCl / various solvent(s) / 0.5 h / Heating View Scheme

1: 1.) NaH / 1.) DMF, 50 deg C, 30 min, 2.) DMF, 50 deg C, 1 h 2: 81 percent / 6 N HCl / various solvent(s) / 0.5 h / Heating View Scheme