N-亚苄基-4-甲氧基苯胺合成路线 （共 139 条）
参考文献
Pfleger; Jaeger
Chemische Berichte, 1957 , vol. 90, p. 2460,2470
反应条件
in tetrahydrofuran
T=70°C; 24 h; Inert atmosphere; optical yield given as percent destereoselective reaction;
参考文献
Shao, You-Dong; Wu, Xue-Song; Tian, Shi-Kai
European Journal of Organic Chemistry, 2012 , # 8 p. 1590 - 1596
反应条件
1.1: LDA / tetrahydrofuran / 0.17 h / -78 °C
1.2: 78 percent / tetrahydrofuran / 0.5 h / -78 °C
2.1: 94 percent / t-BuOK / tetrahydrofuran / 0.67 h / 70 °C
3.1: EtMgBr / tetrahydrofuran / -78 - 20 °C
3.2: CuI / tetrahydrofuran / 0.17 h / 20 °C
3.3: 94 percent / tetrahydrofuran / 0.5 h / 20 °C
4.1: H2 / Pd(OH)2/C / methanol; ethyl acetate
5.1: cerium(IV) ammonium nitrate / acetonitrile; H2O / 0.5 h / 0 °C
6.1: 412 mg / 4-(dimethylamino)pyridine; pyridine / 1 h / 20 °C
View Scheme
参考文献
Satoh, Tsuyoshi; Fukuda, Yuta
Tetrahedron, 2003 , vol. 59, # 49 p. 9803 - 9810
反应条件
1.1: LDA / tetrahydrofuran / 0.17 h / -78 °C
1.2: 69 percent / tetrahydrofuran / 0.5 h / -78 °C
2.1: 98 percent / t-BuOK / tetrahydrofuran / 0.67 h / 70 °C
3.1: EtMgBr / tetrahydrofuran / -78 - 20 °C
3.2: CuI / tetrahydrofuran / 0.17 h / 20 °C
3.3: 89 percent / tetrahydrofuran / 0.5 h / 20 °C
4.1: H2 / Pd(OH)2/C / methanol; ethyl acetate
5.1: cerium(IV) ammonium nitrate / acetonitrile; H2O / 0.5 h / 0 °C
6.1: 4-(dimethylamino)pyridine; pyridine / 1 h / 20 °C
View Scheme
参考文献
Satoh, Tsuyoshi; Fukuda, Yuta
Tetrahedron, 2003 , vol. 59, # 49 p. 9803 - 9810
反应条件
ytterbium(III) triflate in acetonitrile
T=20°C; Mannich reaction; Inert atmosphere; chemoselective reaction;
参考文献
Dupre, Nathalie; Remy, Pauline; Micoine, Kevin; Boglio, Cecile; Thorimbert, Serge; Lacote, Emmanuel; Hasenknopf, Bernold; Malacria, Max
Chemistry - A European Journal, 2010 , vol. 16, # 24 p. 7256 - 7264
反应条件
1: Oxonereg;; acetic acid; sulfuric acid / water / 24 h / 45 °C
2: ethanol / |Reflux
View Scheme
参考文献
Venkatesh; Karunakaran
Asian Journal of Chemistry, 2014 , vol. 26, # 3 art. no. 15506, p. 739 - 744
反应条件
1: Oxonereg;; acetic acid; sulfuric acid / water / 24 h / 45 °C
2: ethanol / |Reflux
View Scheme
参考文献
Venkatesh; Karunakaran
Asian Journal of Chemistry, 2014 , vol. 26, # 3 art. no. 15506, p. 739 - 744
反应条件
1: Oxonereg;; acetic acid; sulfuric acid / water / 24 h / 45 °C
2: ethanol / |Reflux
View Scheme
参考文献
Venkatesh; Karunakaran
Asian Journal of Chemistry, 2014 , vol. 26, # 3 art. no. 15506, p. 739 - 744
反应条件
benzaldehyde; trifluoroacetic acid in 1-methyl-pyrrolidin-2-one
T=-40 - -25°C; Mannich reaction; 3 h;
参考文献
Hayashi, Yujiro; Urushima, Tatsuya; Shoji, Mitsuru; Uchimaru, Tadafumi; Shiina, Isamu
Advanced Synthesis and Catalysis, 2005 , vol. 347, # 11-13 p. 1595 - 1604
反应条件
in dichloromethane
T=20°C;
参考文献
Boehm, Maximillian; Proksch, Kerstin; Mahrwald, Rainer
European Journal of Organic Chemistry, 2013 , # 6 p. 1046 - 1049
