5-[[5-羟基-4-(甲氧基甲基)-6-甲基-吡啶-3-基]甲基二巯基甲基]-4-(甲氧基甲基)-2-甲基-吡啶-3-醇二盐酸盐合成路线 （共 2 条）
反应条件
1: 95.5 percent / SOCl2 / diethyl ether / 4 h / Heating
2: 1.) Na2S2O3, 2.) (NH2)2CS, 1N aq. HCl / 1.) 50percent aq. ETOH, 80 deg C, 3 h, 2.) 85-90 deg C, 3 h
View Scheme
参考文献
Kovler, M. A.; Avakumov, V. M.; Lobanova, M. L.; Alekseeva, Zh. P.; Zhukova, Z. N.; et al.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 2 p. 79 - 81
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 2 p. 22 - 24
反应条件
hydrogenchloride; sodium thiosulfate; thiourea
1.) 50percent aq. ETOH, 80 deg C, 3 h, 2.) 85-90 deg C, 3 h; Yield given. Multistep reaction;
参考文献
Kovler, M. A.; Avakumov, V. M.; Lobanova, M. L.; Alekseeva, Zh. P.; Zhukova, Z. N.; et al.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 2 p. 79 - 81
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 2 p. 22 - 24
