5-(苄氧基)-2,3-二氢-1H-茚-1-酮合成路线 （共 15 条）
反应条件
1: potassium permanganate / benzene / |Reflux; |Dean-Stark 2: palladium 10 on activated carbon; hydrogen / ethyl acetate / 20 °C 3: acetonitrile-D3; water-d2 / |Photolysis View Scheme
参考文献
Kammath, Viju Balachandran; Solomek, Tomas; Ngoy, Bokolombe Pitchou; Heger, Dominik; Klan, Petr; Rubina, Marina; Givens, Richard S.
Journal of Organic Chemistry, 2013 , vol. 78, # 5 p. 1718 - 1729
反应条件
1: potassium permanganate / benzene / |Reflux; |Dean-Stark 2: palladium 10 on activated carbon; hydrogen / ethyl acetate / 20 °C 3: water / acetonitrile-D3 / |Photolysis View Scheme
参考文献
Kammath, Viju Balachandran; Solomek, Tomas; Ngoy, Bokolombe Pitchou; Heger, Dominik; Klan, Petr; Rubina, Marina; Givens, Richard S.
Journal of Organic Chemistry, 2013 , vol. 78, # 5 p. 1718 - 1729
反应条件
sodium tetrahydroborate in tetrahydrofuran; methanol T=20°C; 2 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1688138 A1, 2006 ;
Location in patent: Page/Page column 81 ;
EP 1688138 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 5 h; Inert atmosphere;
参考文献
Reniers; Meinguet; Moineaux; Masereel; Vincent; Frederick; Wouters
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 6104 - 6111
反应条件
tributylphosphine; 1,1'-azodicarbonyl-dipiperidine in tetrahydrofuran
T=20°C; 16 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1688138 A1, 2006 ;
Location in patent: Page/Page column 80-81 ;
EP 1688138 A1
反应条件
potassium carbonate; potassium iodide in N,N-dimethyl-formamide
T=100°C; 2 h;
参考文献
Miyake; Itoh; Tada; Tanabe; Hirata; Oka
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 7 p. 2329 - 2348
反应条件
1: AlCl3 / toluene
2: K2CO3
View Scheme
参考文献
Herzig, Yaacov; Lerman, Lena; Goldenberg, Willy; Lerner, David; Gottlieb, Hugo E.; Nudelman, Abraham
Journal of Organic Chemistry, 2006 , vol. 71, # 11 p. 4130 - 4140
反应条件
1.1: potassium carbonate / acetonitrile / 20 °C
2.1: copper(ll) bromide / chloroform; ethyl acetate / Reflux
3.1: sodium hydride / N,N-dimethyl-formamide / 5 - 20 °C / Inert atmosphere
3.2: 20 °C
4.1: benzene / Irradiation
View Scheme
参考文献
Sebej, Peter; Lim, Bum Hee; Park, Bong Ser; Givens, Richard S.; Klan, Petr
Organic Letters, 2011 , vol. 13, # 4 p. 644 - 647
反应条件
1: acetonitrile / Irradiation
2: potassium carbonate / acetonitrile / 20 °C
View Scheme
参考文献
Sebej, Peter; Lim, Bum Hee; Park, Bong Ser; Givens, Richard S.; Klan, Petr
Organic Letters, 2011 , vol. 13, # 4 p. 644 - 647
反应条件
1.1: copper(ll) bromide / chloroform; ethyl acetate / Reflux
2.1: sodium hydride / N,N-dimethyl-formamide / 5 - 20 °C / Inert atmosphere
2.2: 20 °C
3.1: benzene / Irradiation
View Scheme
参考文献
Sebej, Peter; Lim, Bum Hee; Park, Bong Ser; Givens, Richard S.; Klan, Petr
Organic Letters, 2011 , vol. 13, # 4 p. 644 - 647
