(2R)-2-[(甲基氨基)甲基]-1-吡咯烷羧酸叔丁酯合成路线 （共 4 条）
反应条件
1: 2-methylcarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester With borane-THF in tetrahydrofuran
T=0 - 20°C; 18 h;
2: methylamine in tetrahydrofuran
T=20°C; 18 h;
参考文献
BIOGEN IDEC MA INC.
Patent: WO2004/92171 A2, 2004 ;
Location in patent: Page 24-25 ;
WO 2004/092171 A2
反应条件
borane-THF in tetrahydrofuran
T=20°C; 18 h;
参考文献
Vu, Chi B.; Pan, Deborah; Peng, Bo; Kumaravel, Gnanasambandam; Smits, Glenn; Jin, Xiaowei; Phadke, Deepali; Engber, Thomas; Huang, Carol; Reilly, Jennifer; Tam, Stacy; Grant, Donna; Hetu, Gregg; Petter, Russell C.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 2009 - 2018
反应条件
1: With 4-methyl-morpholine; benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in tetrahydrofuran
T=20°C; 18 h;
2: With THF*DH3 in tetrahydrofuran
T=20°C; 18 h;
参考文献
BIOGEN IDEC MA INC.
Patent: WO2004/92170 A2, 2004 ;
Location in patent: Page 32; 33 ;
WO 2004/092170 A2
反应条件
1.1: EDC; HOBT; N-methylmorpholine / tetrahydrofuran / 0.5 h / 20 °C
1.2: 100 percent / tetrahydrofuran / 18 h / 20 °C
2.1: 100 percent / BH3*THF / tetrahydrofuran / 18 h / 20 °C
View Scheme
参考文献
Vu, Chi B.; Pan, Deborah; Peng, Bo; Kumaravel, Gnanasambandam; Smits, Glenn; Jin, Xiaowei; Phadke, Deepali; Engber, Thomas; Huang, Carol; Reilly, Jennifer; Tam, Stacy; Grant, Donna; Hetu, Gregg; Petter, Russell C.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 2009 - 2018
