甲基-5-脱氧-2,3-O-异亚丙基-D-呋喃核糖苷合成路线 （共 7 条）
反应条件
hydrogen; triethylamine; 1 Pd/C in methanol T=20°C; 24 h; Inert atmosphere;
参考文献
CRYSTAL BIOPHARMACEUTICAL LLC; CHEN, Yu; CHEN, Yi
Patent: WO2010/85377 A2, 2010 ;
Location in patent: Page/Page column 53-54 ;
WO 2010/085377 A2
反应条件
1: With sodium tetrahydroborate in dimethyl sulfoxide T=80 - 85°C; Inert atmosphere; 2: With acetic acid in dimethyl sulfoxide T=10 - 30°C;
参考文献
WO2010/65586 A2, ;
Page/Page column 22 ;
反应条件
potassium hydroxide; hydrogen; palladium on activated charcoal in methanol 15 h; Ambient temperature;
参考文献
Kiss; D'Souza; Van Koeveringe; Arnold
Helvetica Chimica Acta, 1982 , vol. 65, # 5 p. 1522 - 1537
反应条件
1: methyl triphenoxyphosphonium iodide / dimethylformamide / 1 h / 10 °C 2: H2; ammonium hydroxide / Pd/C / ethanol / 4.5 h / 2585.74 Torr View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 19, # 1-2 p. 155 - 174
反应条件
1: HClO4 2: 85 percent / Ph3P, Br2 / CH2Cl2 / 1.) 5-8 deg C, 60 min; 2.) reflux, 4 h; 3.) 20-24 deg C, 14 h 3: 90 percent / KOH, H2 / 5percent Pd/C / methanol / 15 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 65, # 5 p. 1522 - 1537
反应条件
1: 1N HCl / H2O / 2 h / 110 °C 2: pyridine / 20 h / 20 °C View Scheme
参考文献
Kiss; D'Souza; Van Koeveringe; Arnold
Helvetica Chimica Acta, 1982 , vol. 65, # 5 p. 1522 - 1537
反应条件
1: 1N HCl / H2O / 2 h / 110 °C 2: pyridine / 20 h / 20 °C 3: 65 percent / CF3SO2OSiMe3, hexamethyldisilazane / CH2Cl2 / 20 h / Ambient temperature 4: 97 percent / CH3ONa / methanol / Ambient temperature View Scheme
参考文献
Kiss; D'Souza; Van Koeveringe; Arnold
Helvetica Chimica Acta, 1982 , vol. 65, # 5 p. 1522 - 1537
