(S)-2,5-二氢-3,6-二甲氧基-2-异丙基吡嗪合成路线 （共 11 条）
反应条件
in dichloromethane 72 h; Ambient temperature;
参考文献
Schoellkopf, Ulrich; Groth, Ulrich; Deng, Chuanzheng
Angewandte Chemie, 1981 , vol. 93, # 9 p. 793 - 795
反应条件
1: 96 percent / tetrahydrofuran; toluene / 4 h / 50 - 60 °C 2: Et3N / CHCl3; tetrahydrofuran / 13 h / -78 - -20 °C 3: toluene / 24 h / Heating 4: 45 g / CH2Cl2 / 72 h View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 2 p. 321 - 327
反应条件
1: Et3N / CHCl3; tetrahydrofuran / 13 h / -78 - -20 °C 2: toluene / 24 h / Heating 3: 45 g / CH2Cl2 / 72 h View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 2 p. 321 - 327
反应条件
1.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C 2.1: triethylamine / dichloromethane / 0.5 h 2.2: 18 h / 20 °C 3.1: 1,2-dichloro-benzene / 18 h / 175 - 180 °C 4.1: dichloromethane / 84 h / 20 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 9, # 2 p. 185 - 187
反应条件
1.1: triethylamine / dichloromethane / 0.5 h 1.2: 18 h / 20 °C 2.1: 1,2-dichloro-benzene / 18 h / 175 - 180 °C 3.1: dichloromethane / 84 h / 20 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 9, # 2 p. 185 - 187
反应条件
1: triethylamine / CHCl3; tetrahydrofuran / -70 deg C, 3 h; room temp., 30 min 2: toluene / 12 h / Heating 3: 82 percent / CH2Cl2 / 72 h / Ambient temperature View Scheme
参考文献
Angewandte Chemie, , vol. 93, # 9 p. 793 - 795
反应条件
1: toluene / 24 h / Heating 2: 45 g / CH2Cl2 / 72 h View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 2 p. 321 - 327
反应条件
1: toluene / 12 h / Heating 2: 82 percent / CH2Cl2 / 72 h / Ambient temperature View Scheme
参考文献
Angewandte Chemie, , vol. 93, # 9 p. 793 - 795
反应条件
1: n-BuLi / tetrahydrofuran / 8 h / -78 °C 2: LiAlH4 / tetrahydrofuran / -20 °C 3: pyridine / 0 °C 4: 95 percent / NaI / acetone / 2 h / Heating 5: 19 percent / n-BuLi / tetrahydrofuran / 6 h / -78 °C 6: HCl / 2 h / Heating View Scheme
参考文献
Bull, Steven D.; Chernega, Alexander N.; Davies, Stephen G.; Moss, William O.; Parkin, Richard M.
Tetrahedron, 1998 , vol. 54, # 35 p. 10379 - 10388
反应条件
1: 62 percent / n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 45 min, 2.) -78 deg C, 1 h 2: 1.) 0.25 M HCl, 2.) Et3N / 1.) THF, r.t., 90 min, 2.) DMF, 60 deg C, 30 min View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 29, # 2 p. 218 - 221
