2,3,4,5,6-五氟联苯合成路线 （共 79 条）
反应条件
1: aniline With tert.-butylnitrite; boron trifluoride diethyl etherate in tetrahydrofuran T=-15 - 20°C; Schlenk techniqueInert atmosphere; 2: 2,3,4,5,6-pentafluorobenzene With potassium phosphate; copper(l) iodide; 1,10-phenanthroline; tetra-(n-butyl)ammonium iodide in dimethyl sulfoxide; acetonitrile T=130°C; 4 h; Schlenk technique;
参考文献
Zhu, Xingyi; Li, Feng; Su, Weike
Tetrahedron Letters, 2013 , vol. 54, # 10 p. 1285 - 1289
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; potassium carbonate in isopropanol acetate T=80°C; 12 h;
参考文献
Lafrance, Marc; Shore, Daniel; Fagnou, Keith
Organic Letters, 2006 , vol. 8, # 22 p. 5097 - 5100
反应条件
copper(l) iodide in diethylene glycol dimethyl ether T=130°C; 24 h; Inert atmosphere;
参考文献
Shang, Rui; Fu, Yao; Wang, Yan; Xu, Qing; Yu, Hai-Zhu; Liu, Lei
Angewandte Chemie - International Edition, 2009 , vol. 48, # 49 p. 9350 - 9354
反应条件
palladium diacetate; potassium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; silver(l) oxide in toluene T=100°C; 8 h; Inert atmosphere; Reagent/catalyst;
参考文献
Tetrahedron, , vol. 70, # 23 p. 3720 - 3725
反应条件
1: pentafluorophenyldihydroxyborane With KHF2 in methanol; water T=20°C; 4 h; 2: iodobenzene With silver(l) oxide; bis-triphenylphosphine-palladium(II) chloride in toluene T=100°C; Suzuki-Miyaura cross-coupling; 8 h; Further stages.;
参考文献
Adonin, Nicolay Yu.; Babushkin, Dmitrii E.; Parmon, Valentin N.; Bardin, Vadim V.; Kostin, Gennadiy A.; Mashukov, Vasiliy I.; Frohn, Hermann-Josef
Tetrahedron, 2008 , vol. 64, # 25 p. 5920 - 5924
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; potassium carbonate in isopropanol acetate T=80°C; 12 h;
参考文献
Lafrance, Marc; Shore, Daniel; Fagnou, Keith
Organic Letters, 2006 , vol. 8, # 22 p. 5097 - 5100
反应条件
potassium carbonate; triphenylphosphine; silver(l) oxide; palladium diacetate in toluene T=100°C; 3 h;
参考文献
Frohn; Adonin; Bardin; Starichenko
Tetrahedron Letters, 2002 , vol. 43, # 45 p. 8111 - 8114
反应条件
potassium carbonate; colloid Cu/Pd in N,N-dimethyl-formamide T=110°C; Suzuki coupling; 2 h;
参考文献
Journal of the American Chemical Society, , vol. 124, # 40 p. 11858 - 11859
反应条件
tri-tert-butyl phosphine; cesium fluoride; silver(l) oxide; tris-(dibenzylideneacetone)dipalladium(0) in N,N-dimethyl-formamide T=100°C; Suzuki-Miyaura coupling; 12 h;
参考文献
Korenaga, Toshinobu; Kosaki, Takahiro; Fukumura, Rokki; Ema, Tadashi; Sakai, Takashi
Organic Letters, 2005 , vol. 7, # 22 p. 4915 - 4917
反应条件
palladium diacetate; potassium carbonate; 4-methyl-benzoic acid; silver carbonate in dimethylammonium 2,4-dichlorophenoxyacetate T=110°C; 10 h;
参考文献
Wei, Ye; Kan, Jian; Wang, Min; Su, Weiping; Hong, Maochun
Organic Letters, 2009 , vol. 11, # 15 p. 3346 - 3349
