1-(4-甲氧基苯基)-2-苯基-1-丁酮合成路线 （共 21 条）
反应条件
1: 1.) Mg / 1.) ether, 2.) reflux, 3 h, ether 2: pyridine hydrochloride / 3.5 h / 220 °C 3: 84 percent / 1.5M NaOH, Bu4NHSO4, 2,6-di-t-butyl-4-methylphenol / H2O / 3 h / Heating 4: 86 percent / methanol / 16 h / 65 °C View Scheme
参考文献
Jarman, Michael; McCague, Raymond
Journal of Chemical Research, Miniprint, 1985 , # 4 p. 1342 - 1388
反应条件
1: 1.) Mg / 1.) ether, 2.) reflux, 3 h, ether 2: pyridine hydrochloride / 3.5 h / 220 °C 3: 1.) NaH / 1.) DMF, 2.) 50 deg C View Scheme
参考文献
Jarman, Michael; McCague, Raymond
Journal of Chemical Research, Miniprint, 1985 , # 4 p. 1342 - 1388
反应条件
1: 1.) Mg / 1.) ether, 2.) reflux, 3 h, ether 2: pyridine hydrochloride / 3.5 h / 220 °C 3: 1.) NaH / 1.) DMF, 2.) 60 deg C, 30 min View Scheme
参考文献
Jarman, Michael; McCague, Raymond
Journal of Chemical Research, Miniprint, 1985 , # 4 p. 1342 - 1388
反应条件
AlCl3, aluminium chloride
T=0 - 20°C; Friedel Crafts Acylation; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/33056 A2, 2005 ;
Location in patent: Page/Page column 30; 38-40 ;
WO 2005/033056 A2
反应条件
trifluoroacetic anhydride
T=22 - 30°C; 3.2 h;
参考文献
Jarman, Michael; McCague, Raymond
Journal of Chemical Research, Miniprint, 1985 , # 4 p. 1342 - 1388
反应条件
zeolite Hβ in dichloromethane
4 h; Heating;
参考文献
Smith, Keith; El-Hiti, Gamal A.; Jayne, Anthony J.; Butters, Michael
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 13 p. 2321 - 2325
反应条件
clay K10
T=120°C; 4 h;
参考文献
Smith, Keith; El-Hiti, Gamal A.; Jayne, Anthony J.; Butters, Michael
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 13 p. 2321 - 2325
参考文献
Ney
Chemische Berichte, 1888 , vol. 21, p. 2453
反应条件
1: 76.8 percent / aluminium chloride / 1,2-dichloro-ethane / 2 h / Heating
2: potassium tert-butylate / diethyl ether / Heating
View Scheme
参考文献
Lubczyk, Veronika; Bachmann, Helmut; Gust, Ronald
Journal of Medicinal Chemistry, 2002 , vol. 45, # 24 p. 5358 - 5364
反应条件
1: 76.8 percent / aluminium chloride / 1,2-dichloro-ethane / 2 h / Heating
2: potassium tert-butylate / diethyl ether / Heating
View Scheme
参考文献
Lubczyk, Veronika; Bachmann, Helmut; Gust, Ronald
Journal of Medicinal Chemistry, 2002 , vol. 45, # 24 p. 5358 - 5364
