1-(4-甲氧基苯基)-2-苯基-1-丁酮合成路线 （共 21 条）
反应条件
1: 38 percent / 48 h / Heating
2: NaOEt / ethanol / 4.17 h / Heating
View Scheme
参考文献
Schneider, Martin R.; Angerer, Erwin von; Schoenenberger, Helmut; Michel, Ralf Th.; Fortmeyer, H. P.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1070 - 1077
反应条件
sodium ethanolate in ethanol
4.17 h; Heating;
参考文献
Schneider, Martin R.; Angerer, Erwin von; Schoenenberger, Helmut; Michel, Ralf Th.; Fortmeyer, H. P.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1070 - 1077
反应条件
potassium tert-butylate in diethyl ether
Heating;
参考文献
Lubczyk, Veronika; Bachmann, Helmut; Gust, Ronald
Journal of Medicinal Chemistry, 2002 , vol. 45, # 24 p. 5358 - 5364
反应条件
1: phosphoric acid / 10 °C
2: 0.33 h / 10 °C
View Scheme
参考文献
Smyth, Timothy P.; Corby, Brian W.
Journal of Organic Chemistry, 1998 , vol. 63, # 24 p. 8946 - 8951
反应条件
toluene
und Hydrolyse des entstandenen Imids mit siedender alkoholischer Salzsaeure;
参考文献
Ramart-Lucas; Anagnostopoulos
Bulletin de la Societe Chimique de France, 1928 , vol. <4>43, p. 1353
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1928 , vol. 186, p. 1628
反应条件
pyridine hydrochloride
Heating;
参考文献
Klinge Pharma GmbH and Co.
Patent: US5047431 A1, 1991 ;
US 5047431 A
反应条件
1: Py*HCl / Heating
2: (i) NaOEt, EtOH, (ii) /BRN= 605280/, benzene
View Scheme
参考文献
Imperial Chemical Industries, Ltd.
Patent: BE637389 , 1964 ;
Chem.Abstr., 1965 , vol. 62, # 10373
反应条件
1: tetrahydrofuran / Heating
2: 47percent HBr / tetrahydrofuran
View Scheme
参考文献
Lubczyk, Veronika; Bachmann, Helmut; Gust, Ronald
Journal of Medicinal Chemistry, 2002 , vol. 45, # 24 p. 5358 - 5364
反应条件
1: tetrahydrofuran / Heating
2: 47percent HBr / tetrahydrofuran
3: 62.4 percent / BBr3 / CH2Cl2 / 72 h / 20 °C
View Scheme
参考文献
Lubczyk, Veronika; Bachmann, Helmut; Gust, Ronald
Journal of Medicinal Chemistry, 2002 , vol. 45, # 24 p. 5358 - 5364
反应条件
1: 1.) Mg / 1.) ether, 2.) reflux, 3 h, ether
2: pyridine hydrochloride / 3.5 h / 220 °C
3: 84 percent / 1.5M NaOH, Bu4NHSO4, 2,6-di-t-butyl-4-methylphenol / H2O / 3 h / Heating
4: 94 percent / dimethylformamide / 1.5 h / 80 °C
View Scheme
参考文献
Jarman, Michael; McCague, Raymond
Journal of Chemical Research, Miniprint, 1985 , # 4 p. 1342 - 1388
