2-(二甲氨基甲基)-4-(2-氨乙基硫甲基)噻唑合成路线 (共 7 条)
反应条件
1: 2-mercaptoethanamine hydrochloride With sodium hydroxide; hydroxylammonium sulphate in water T=5 - 10°C; 1 h; 2: 4-chloromethyl-2-dimethylaminomethylthiazole in water T=10°C; 1 h;
参考文献
KUMAR, Dinesh, R.
Patent: WO2004/69817 A1, 2004 ;
Location in patent: Page 8 ;
反应条件
sodium hydroxide in dichloromethane; water
反应条件
hydrogen bromide in water
参考文献
US4468399 A1, ;
US 4468399 A
参考文献
US4471122 A1, ;
US 4471122 A
US4394508 A1, ;
US 4394508 A
反应条件
hydrogen bromide in water T=100°C; 11 h;
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 35, # 3 p. 573 - 577
反应条件
1: LiAlH4 / tetrahydrofuran / 0 °C 2: conc. HBr / H2O / 11 h / 100 °C View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 35, # 3 p. 573 - 577
反应条件
in water T=20 - 35°C; 8 h;
参考文献
KUMAR, Dinesh, R.
Patent: WO2004/69817 A1, 2004 ;
Location in patent: Page 8,9 ;