2-二甲胺基甲基-4-羟甲基噻唑合成路线 (共 8 条)
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; Yield given;
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 35, # 3 p. 573 - 577
参考文献
PFIZER INC.
Patent: EP807633 A2, 1997 ;
反应条件
sodium in deuterated toluene T=20 - 25°C; 1 h; other bases, other solvents; Product distributionMechanism;
参考文献
Journal of Organic Chemistry, , vol. 57, # 10 p. 2869 - 2872
反应条件
hydrogen bromide in water
参考文献
Eli Lilly and Company
Patent: US4468399 A1, 1984 ;
US 4468399 A
参考文献
Bristol-Myers Company
Patent: US4510309 A1, 1985 ;
US 4510309 A
反应条件
hydrogen bromide in water T=100°C; 11 h;
参考文献
Trumm; Sattler; Postius; Szelenyi; Schunack
Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 3 p. 573 - 577
反应条件
manganese(IV) oxide in chloroform
2 h; Heating / reflux;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1612204 A1, 2006 ;
Location in patent: Page/Page column 47-48 ;
参考文献
PFIZER INC.
Patent: EP807633 A2, 1997 ;