3,5-二甲基-3H-咪唑-4-羧酸合成路线 (共 2 条)
反应条件
1: With water; sodium hydroxide in tetrahydrofuran; methanol
T=20°C;
2: in tetrahydrofuran; methanol
pH=4 - 5;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2530078 A1, 2012 ;
Location in patent: Page/Page column 148 ;
反应条件
Erhitzen ueber den Schmelzpunkt;
参考文献
Hubball; Pyman
Journal of the Chemical Society, 1928 , p. 28