3,5-双三氟甲基苯甲酰氯合成路线 （共 20 条）
反应条件
oxalyl dichloride in dichloromethane; N,N-dimethyl-formamide T=0°C; 1 h;
参考文献
ZALICUS PHARMACEUTICALS LTD.; PAJOUHESH, Hassan, A.; HOLLAND, Richard; ZHANG, Lingyun; PAJOUHESH, Hossein, O.; LAMONTAGNE, Jason; WHELAN, Brendan; SHORT, Glenn, F., III.; ROMERO, Donna, L.
Patent: WO2013/131018 A1, 2013 ;
Location in patent: Page/Page column 56 ;
反应条件
tetrachlorosilane; triphenylphosphine; aluminium trichloride
反应条件
thionyl chloride; N,N-dimethyl-formamide in chloroform T=20°C; 1 h; Reflux; Product distribution / selectivity;
参考文献
US2009/227611 A1, ;
Page/Page column 11 ;
反应条件
2: (i) Mg, I2, Et2O, (ii) /BRN= 1900390/ 3: SOCl2 View Scheme
参考文献
Bulletin de la Societe Chimique de France, , p. 587 - 593
反应条件
1: (i) Mg, I2, Et2O, (ii) /BRN= 1900390/ 2: SOCl2 View Scheme
参考文献
Bulletin de la Societe Chimique de France, , p. 587 - 593
反应条件
1: diethyl ether / 0 °C 2: aq. Ag2O / dioxane 3: (COCl)2; DMF / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 15 p. 1723 - 1727
反应条件
hydrogen sulfide; palladium in quinoline; water; toluene
参考文献
Baumann, Kathe; Marhold, Albrecht
Patent: US2002/38055 A1, 2002 ;
反应条件
1: 83 percent Chromat. / HCOONH4 / Ru3(CO)12 / dioxane / 20 h / 160 °C View Scheme
参考文献
Chatani; Tatamidani; Ie; Kakiuchi; Murai
Journal of the American Chemical Society, 2001 , vol. 123, # 20 p. 4849 - 4850
反应条件
hydrogen; quinoline; 5 palladium on barium sulfate; sulfur in toluene T=100 - 110°C; 12 h;
参考文献
BAYER AG
Patent: EP1191012 A1, 2002 ;
Location in patent: Page 4 ;
反应条件
hydrogen sulfide; palladium in quinoline; water; toluene
参考文献
Baumann, Kathe; Marhold, Albrecht
Patent: US2002/38055 A1, 2002 ;
