2-溴甲基-噻唑-4-羧酸乙酯合成路线 （共 7 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1612204 A1, 2006 ;
Location in patent: Page/Page column 47 ;
反应条件
1: acetonitrile / 14 h / 20 °C 2: methanol / dichloromethane / 2 h / 20 °C View Scheme
参考文献
SANOFI
Patent: US2012/129830 A1, 2012 ;
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane
4 h; Irradiation;
参考文献
Hallinan; Hagen, Timothy J.; Tsymbalov, Sofya; Stapelfeld, Awilda; Savage, Michael A.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 1 p. 1 - 6
反应条件
N-bromosuccinmide; dibenzoyl peroxide in 1,2-dichloro-ethane
T=70°C; 85 h;
参考文献
Dhar, T. G. Murali; Potin, Dominique; Maillet, Magali Jeannine Blandine; Launay, Michele; Nicolai, Eric Antoine; Iwanowicz, Edwin J.
Patent: US2004/9998 A1, 2004 ;
Location in patent: Page/Page column 40 ;
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
Zeneca Limited
Patent: US5965741 A1, 1999 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
36 h;
参考文献
Charrier, Cedric; Roche, Joelle; Gesson, Jean-Pierre; Bertrand, Philippe
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 22 p. 6142 - 6146
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile; dibenzoyl peroxide in tetrachloromethane
1.5 h; Heating; Product distribution;
参考文献
Krieg, Benno; Mittner, Juergen
Liebigs Annalen der Chemie, 1981 , # 4 p. 623 - 632
