2-(苄氧基)-4-溴苯甲醚合成路线 （共 10 条）
反应条件
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C 1.2: tetrahydrofuran / 2 h / -78 °C 2.1: HCl; water / diethyl ether View Scheme
参考文献
Synthetic Communications, , vol. 29, # 15 p. 2719 - 2730
反应条件
1.1: n-butyllithium / tetrahydrofuran / -78 °C 1.2: -78 °C 2.1: palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 24 h View Scheme
参考文献
Combes, Sebastien; Barbier, Pascale; Douillard, Soazig; McLeer-Florin, Anne; Bourgarel-Rey, Veronique; Pierson, Jean-Thomas; Fedorov, Alexey Yu.; Finet, Jean-Pierre; Boutonnat, Jean; Peyrot, Vincent
Journal of Medicinal Chemistry, 2011 , vol. 54, # 9 p. 3153 - 3162
反应条件
1.1: n-butyllithium / tetrahydrofuran / -78 °C 1.2: -78 °C 2.1: palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 24 h 3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; benzene / Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 9 p. 3153 - 3162
反应条件
potassium carbonate in acetone; acetonitrile
18 h; Heating;
参考文献
Yu, Younong; Singh, Sudhir K.; Liu, Angela; Li, Tsai-Kun; Liu, Leroy F.; LaVoie, Edmond J.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1475 - 1491
反应条件
triphenylphosphine; diethylazodicarboxylate in toluene
T=20°C; 2 h; Inert atmosphere;
参考文献
Woodring, Jennifer L.; Bland, Nicholas D.; Ochiana, Stefan O.; Campbell, Robert K.; Pollastri, Michael P.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5971 - 5974
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 3 h;
参考文献
Eisai Co., Ltd.
Patent: EP1394147 A1, 2004 ;
Location in patent: Page 179 ;
反应条件
potassium carbonate; sodium iodide in acetone
10 h; Heating;
参考文献
Chaffee, Alan L.; Cooke, Raymond G.; Dagley, Ian J.; Perlmutter, Patrick; Thomas, Raymond L.
Australian Journal of Chemistry, 1981 , vol. 34, # 3 p. 587 - 598
反应条件
1: 0.75 g / NaOH / H2O; tetrahydrofuran / 5 h / Heating
2: 0.52 g / K2CO3 / dimethylformamide / 12 h / 80 °C
View Scheme
参考文献
Kurono, Nobuhito; Inoue, Tomio; Tokuda, Masao
Tetrahedron, 2005 , vol. 61, # 47 p. 11125 - 11131
反应条件
1: 92 percent / m-CPBA / CH2Cl2 / 48 h / 20 °C
2: 96 percent / K2CO3 / acetonitrile; acetone / 18 h / Heating
View Scheme
参考文献
Yu, Younong; Singh, Sudhir K.; Liu, Angela; Li, Tsai-Kun; Liu, Leroy F.; LaVoie, Edmond J.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1475 - 1491
反应条件
1.1: trifluoroacetic acid; potassium tert-butylate / acetonitrile / 0.75 h / 20 °C
1.2: 20 °C
2.1: triphenylphosphine; diethylazodicarboxylate / toluene / 2 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Woodring, Jennifer L.; Bland, Nicholas D.; Ochiana, Stefan O.; Campbell, Robert K.; Pollastri, Michael P.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5971 - 5974
